SEQanswers - Forum https://www.seqanswers.com/ en Mon, 19 Oct 2026 15:10:13 GMT vBulletin 60 https://www.seqanswers.com/images/misc/rss.png SEQanswers - Forum https://www.seqanswers.com/ Three last-minute places available: 2nd Berlin Winter School in RNA-Seq Data Analysis, November 2–5, 2026 https://www.seqanswers.com/forum/bioinformatics/bioinformatics-aa/327717-three-last-minute-places-available-2nd-berlin-winter-school-in-rna-seq-data-analysis-november-2–5-2026 Mon, 19 Oct 2026 12:40:27 GMT Three participants have just cancelled! 3 places are now available for this fully booked workshop. Register now to secure one of these spot! More...
More information and registration

We are organizing the 2nd Berlin Winter School in RNA-Seq Data Analysis, a four-day, hands-on course for biologists and data analysts with little or no previous experience in NGS bioinformatics.
  • Date: November 2–5, 2026
  • Time: 9:00 am–5:00 pm
  • Location: Berlin, Germany
  • Language: English
  • Registration fee: EUR 1,449 excluding 19% VAT

Participants will work with real bulk RNA-Seq data and cover:
  • Linux and command-line basics for bioinformatics
  • FASTQ quality control and preprocessing
  • Read alignment, split-read mapping and pseudo-alignment
  • SAM/BAM files, mapping statistics and visualization
  • Gene, transcript and exon quantification
  • Differential gene expression with DESeq2
  • Differential splicing and isoform expression
  • Diagnostic graphics and statistics in R
  • Comparison and critical evaluation of different analysis approaches

A basic understanding of molecular biology is sufficient. The course does not cover single-cell RNA-Seq analysis.

Course materials, catering, a conference dinner, a guided city tour, high-performance workstations and a downloadable analysis environment are included. No laptop is required.

Registration will close soon or as soon as all available places have been filled. Places are allocated on a first-come, first-served basis.

More information and registration
​]]> Bioinformatics ecSeq Bioinformatics https://www.seqanswers.com/forum/bioinformatics/bioinformatics-aa/327717-three-last-minute-places-available-2nd-berlin-winter-school-in-rna-seq-data-analysis-november-2–5-2026 Mayo Clinic-Led Study Detects DNA Mutations Across Noncancerous Tissues https://www.seqanswers.com/forum/news/327716-mayo-clinic-led-study-detects-dna-mutations-across-noncancerous-tissues Thu, 15 Oct 2026 18:52:55 GMT A Mayo Clinic-led study has shown how to detect a broad range of DNA mutations in noncancerous human tissues and across the genome. The analysis,... A Mayo Clinic-led study has shown how to detect a broad range of DNA mutations in noncancerous human tissues and across the genome. The analysis, drawing on more than 90 trillion DNA letters of sequencing data, could help scientists study when these changes arise, from early development through aging, and how they contribute to cancer and other diseases.

Published in Cell, the study is the flagship paper in a package of roughly a dozen publications from the NIH Common Fund’s Somatic Mosaicism across Human Tissues, or SMaHT, Network. Researchers evaluated approaches for detecting somatic mutations ranging from single-letter DNA changes to large deletions, insertions and rearrangements.

“We often think of the human genome as a single, fixed sequence, but every person is a mosaic of cells that acquire genetic changes over time,” explained Alexej Abyzov, corresponding author of the Cell study. “As we have increasingly recognized in recent years, these mutations are relevant not only to cancer but also to a broad range of age-related diseases.”

Unlike inherited genetic changes, somatic mutations arise after conception and accumulate over a lifetime. As cells divide, they can pass those changes to new cells, creating genetic differences within the same person known as somatic mosaicism. Some somatic mutations can alter how cells behave and contribute to cancer, aging, and neurodevelopmental, cardiovascular and autoimmune diseases.

These mutations can be difficult to detect when they are rare or occur in complex, repetitive regions of the genome, so the SMaHT Network compared short- and long-read whole-genome sequencing, duplex sequencing, single-cell sequencing, and computational approaches. Long-read sequencing produced one of the clearest findings, detecting about twice as many large DNA changes as short-read sequencing and finding insertions that shorter reads often missed. A more complete genome reference also raised precision in one benchmark from 79% to 89%, and single-cell sequencing of 102 lung and colon cells revealed cell-to-cell differences that helped trace their history back to early development.

Dr. Abyzov also co-led a companion SMaHT paper published in The American Journal of Human Genetics, in which deep whole-genome sequencing accurately detected rare, single-letter DNA changes present at levels below 1% in a tissue sample. Analyzing DNA from different organs helped detect mutations that arose early in development and spread to multiple tissues; combining lung and colon data uncovered 13 additional shared mutations, improving detection by 145% for these very rare mutations compared with analyzing either tissue alone.

SMaHT aims to catalog somatic mutations across 10 to 15 tissue types from 150 donors while improving the tools used to detect them. NIH is planning a second stage focused on understanding how these mutations influence biological processes and disease. Dr. Abyzov says the research could eventually help identify people at higher cancer risk and track precancerous changes in tissues before they develop symptoms.]]> News SEQadmin2 https://www.seqanswers.com/forum/news/327716-mayo-clinic-led-study-detects-dna-mutations-across-noncancerous-tissues Study Finds Chromatin Motion Holds Steady Until Cells Face Stress https://www.seqanswers.com/forum/news/327713-study-finds-chromatin-motion-holds-steady-until-cells-face-stress Wed, 14 Oct 2026 13:39:42 GMT Living human cells appear to hold the local movement of their DNA at a remarkably steady level through most of the cell cycle, only dialing it up... Living human cells appear to hold the local movement of their DNA at a remarkably steady level through most of the cell cycle, only dialing it up when something goes wrong, according to a new study from a team led by Kazuhiro Maeshima at Japan’s National Institute of Genetics.

Genomic DNA is wrapped around core histone proteins to form nucleosomes, the basic units of chromatin, and this dynamic chromatin behavior, tied to chromatin accessibility, plays a critical role in genome functions such as transcription and DNA replication and repair. During interphase, the period between cell divisions, DNA is replicated and the nucleus expands, all while cells continue these essential functions. How DNA’s physical behavior holds up through these large-scale changes had remained unclear. In an earlier study using synchronized human cells, Professor Maeshima’s team found that local chromatin motion stayed nearly constant across the G1, S, and G2 phases. The new study asked whether the same holds true under more natural conditions, in cells growing asynchronously without drug-induced synchronization.

To find out, the researchers combined single-nucleosome imaging with Fucci probes, fluorescent markers that change color as a cell progresses through the cycle, letting them identify each living cell’s cycle stage without chemical synchronization. Using HeLa and HCT116 cells expressing H2B-HaloTag to mark bulk DNA, they tracked individual nucleosomes and matched that movement to each cell’s Fucci signal. Across asynchronously growing cells, average local nucleosome motion remained nearly constant from G1 through S and into G2, even as the genome doubled in content and the nucleus grew substantially in volume.

The team also examined nucleosomes carrying H3.3, a histone variant enriched in active chromatin, or euchromatin. These nucleosomes moved more than bulk H2B-marked nucleosomes overall, but that elevated level of motion likewise stayed constant across interphase, suggesting different chromatin environments each maintain their own characteristic baseline of movement as the cycle progresses.

“Our results show that local DNA motion is maintained at a surprisingly similar level even while DNA is being duplicated and the nucleus is growing,” said Yu Nagata, first author of the study published in Journal of Cell Science. “This near-constant motion may provide similar physical conditions for housekeeping genome functions throughout interphase.”

That stability wasn’t absolute, though. When the researchers inhibited transcription, nucleosome motion increased throughout interphase. Replication stress induced with hydroxyurea and DNA damage induced with cisplatin produced the same effect, each raising average nucleosome motion above its steady baseline.

“Cells seem to maintain local DNA motion near a steady level for routine housekeeping tasks, but they can change this motion when necessary,” Professor Maeshima added. “For example, increased DNA motion after DNA damage may help cells perform ad hoc tasks such as recruiting DNA repair factors.”
]]> News SEQadmin2 https://www.seqanswers.com/forum/news/327713-study-finds-chromatin-motion-holds-steady-until-cells-face-stress Larger Datasets Reveal Additional Switches That Control Gene Expression https://www.seqanswers.com/forum/news/327712-larger-datasets-reveal-additional-switches-that-control-gene-expression Tue, 13 Oct 2026 17:56:14 GMT Most GWAS loci fall in regions that control gene expression rather than in the genes themselves, and linking those variants to eQTL and sQTL signals... Most GWAS loci fall in regions that control gene expression rather than in the genes themselves, and linking those variants to eQTL and sQTL signals has typically hit a discovery limit after a few thousand samples. A new study published in Science suggests that limit was really a limit of dataset size.

The team analyzed 14,324 RNA sequencing samples, including 6,454 whole blood and 1,291 lung samples, from the NHLBI-sponsored Trans-Omics for Precision Medicine (TOPMed) program. After e/sQTL analysis, they mapped tens of thousands of signals at high resolution. Because TOPMed cohorts are more genetically diverse than most prior studies, roughly one in six signals found in whole blood came from variants that are rare or absent in people of European ancestry, and just 1.3% of those appear in the four large eQTL resources built mostly from European samples.

“The more samples you add, the more e/sQTL signals that you detect,” said co-study leader Steve Parker from the University of Michigan. “I think NHLBI has invested very smartly in TOPMed. Although you saturate discovery of main effects after a few thousand samples… the number of independent e/sQTL signals just keeps on growing and growing, which is really cool to see.”

Fine-mapping GWAS signals from the UK Biobank showed that more eQTL signals also meant more overlap with GWAS findings, and the extra signals weren’t redundant: most genes have several independent regulatory switches, and the second, third, and fourth are harder for smaller studies to detect. Of the 10,611 GWAS signals the team connected to a specific gene, roughly two-thirds involved one of these secondary switches.

“Genetic regulation of the expression levels of one part of a biological unit’s machinery, such as a regulator of a cellular stress response, can affect the expression levels of other parts of the same biological machinery,” explained co-author Laura Scott. Parker added that “genetic evidence of drug targets is a huge predictor of clinical success for therapeutics,” more than doubling the rate of success, making the link between genetic variation and target gene expression especially valuable.

Co-author Francois Aguet noted that “another powerful aspect of larger-scale studies is the ability to identify QTL for rarer variants, which tend to have larger effects. As further such studies are conducted across more tissues and cell types, we will likely find a lot more of these effects.”

The findings also point to the value of expanding beyond whole blood and improving ancestral diversity. “In TOPMed, we still have many more distinct signals to discover at most genes, even in whole blood, which will almost certainly provide still more links between GWAS loci and their likely mechanisms,” noted co-author Laura Raffield. “Also, many non-European ancestry populations are still underrepresented in our current dataset… important ancestry-differentiated signals may be missed, even in blood, and certainly in other tissues. These issues will continue to be addressed in future work from TOPMed.”

“Science moves forward with bigger and better data, always,” Parker said. “It’s the equivalent of getting a fancy new microscope except we’re not seeing things in higher resolution in a microscopy image, we’re seeing things in much higher resolution from a genetic association with gene expression perspective.”
]]> News SEQadmin2 https://www.seqanswers.com/forum/news/327712-larger-datasets-reveal-additional-switches-that-control-gene-expression Computational Tool Captures How Chromatin Folds at Scale https://www.seqanswers.com/forum/news/327710-computational-tool-captures-how-chromatin-folds-at-scale Fri, 09 Oct 2026 19:14:25 GMT Studying how chromatin changes requires capturing molecular movements and interactions that are difficult to resolve experimentally. Now, an... Studying how chromatin changes requires capturing molecular movements and interactions that are difficult to resolve experimentally. Now, an international research team led by IRB Barcelona, the University of Cambridge, UT Southwestern Medical Center and the Howard Hughes Medical Institute has developed OpenCGChromatin, a tool that functions as a computational microscope, using simulations to explore how chromatin folds, how its components interact, and what forces hold its structures together.

“The challenge is to connect interactions between individual molecules with the behavior of much larger stretches of chromatin. This tool allows us to study both within the same framework and understand how small molecular changes can alter DNA packaging,” says Modesto Orozco, corresponding author on the study published in Nature Communications.

The tool combines a detailed representation of DNA and proteins with greater computational efficiency, allowing researchers to study chromatin systems more than ten times larger than those accessible to previous models with comparable resolution, including assemblies containing hundreds of nucleosomes. Its simulations reproduce observations from microscopy and biochemical experiments while also revealing movements of flexible histone regions that are difficult to resolve experimentally.

“What Kieran Russell, first author of this study, has achieved is remarkable. He has pushed the state of the art in chromatin modeling, allowing us to simulate systems at a scale and level of molecular detail that were previously out of reach. We can now connect the chemical makeup of chromatin to its organization across scales—from molecular interactions to gene-sized structures and biomolecular condensates—while remaining closely grounded in experiment. I am very excited because OpenCGChromatin opens up a completely new range of questions that we can now address computationally,” says Rosana Collepardo-Guevara e, who also co-led the study.

“The simulations help us understand why changing the spacing between nucleosomes, or adding chemical modifications to histones, can make chromatin behave differently,” adds David Farré-Gil, also an author of the paper.

OpenCGChromatin is available as open-source software, allowing other researchers to use it to investigate the physical principles underlying genome organization.
]]> News SEQadmin2 https://www.seqanswers.com/forum/news/327710-computational-tool-captures-how-chromatin-folds-at-scale Turning NGS Data into Confident Pathogen Detection https://www.seqanswers.com/forum/site-news/webinar-series/327707-turning-ngs-data-into-confident-pathogen-detection Thu, 01 Oct 2026 13:37:21 GMT Next-generation sequencing (NGS) is changing how clinical and public health laboratories detect pathogens, track antimicrobial resistance, and... This webinar will explain the basics of NGS analysis and show how to build a sequencing workflow in a clinical lab, including how to set thresholds for reporting positive detections

Next-generation sequencing (NGS) is changing how clinical and public health laboratories detect pathogens, track antimicrobial resistance, and respond to outbreaks. However, transforming raw sequencing reads into actionable results is a challenge. Scientists in clinical and public health laboratories need a clear analysis process, an understanding of the quality metrics behind each call, and defined criteria for deciding when a detection counts as positive. Without these, sequencing data can be hard to interpret and turn into a validated clinical workflow.

In this webinar brought to you by BugSeq, Jose Alexander from AdventHealth will explain the basics of NGS analysis and show how to build a sequencing workflow in a clinical lab, including how to set thresholds for reporting positive detections. Jennifer Laplante from the New York State Department of Health will share how her team approaches viral sequencing in a public health setting. To close, Sherif Nour will demo BugSeq's fully automated, cloud-based bioinformatics platform, which analyzes DNA and RNA sequencing data within hours, and show where it fits in an efficient lab workflow.

Topics to be covered:

• The basic principles and key metrics behind NGS data analysis evolutionary insights to clinical applications
• How to set up a lab process that takes NGS data from sequencing through analysis
• How to set threshold criteria for calling positive detections with confidence
• How viral sequencing supports public health surveillance
• How automated, cloud-based bioinformatics can make clinical and public health sequencing workflows faster and simpler

Who should attend:

• Clinical microbiologists and medical microbiologists
• Clinical and public health laboratory directors and managers
• Public health laboratory scientists and epidemiologists working on pathogen surveillance
• Medical technologists and clinical laboratory scientists who are moving into sequencing
• Bioinformaticians who support clinical or public health sequencing workflows
• Infection prevention and antimicrobial stewardship professionals who use sequencing data
• Labs that are evaluating or starting to adopt NGS for pathogen detection ]]> Webinar Series SEQadmin2 https://www.seqanswers.com/forum/site-news/webinar-series/327707-turning-ngs-data-into-confident-pathogen-detection Decoding the Genomics of Neurodegeneration with Large-Scale Long-Read Sequencing https://www.seqanswers.com/forum/site-news/webinar-series/327704-decoding-the-genomics-of-neurodegeneration-with-large-scale-long-read-sequencing Thu, 01 Oct 2026 13:06:10 GMT
This webinar will present discoveries of AD/ADRD-relevant mutations made possible by long-read sequencing


Much of the genetic basis of Alzheimer's disease and related dementias (AD/ADRD) is still unexplained, and some of the answers may sit in parts of the genome that standard sequencing cannot read. Short-read sequencing often fails to resolve large structural variants, repeat expansions, and complex genomic regions, so variants that could drive disease go undetected. To close this gap, researchers at the NIH Center for Alzheimer's and Related Dementias (CARD) have built one of the largest long-read whole-genome sequencing resources in human brain tissue.

In this webinar, brought to you by Oxford Nanopore, Kimberley Billingsley, the head of the Translational Neurogenomics Group at CARD, will present discoveries of AD/ADRD-relevant mutations made possible by long-read sequencing. She will cover how haplotype-resolved methylation at key loci such as APOE points to new layers of epigenetic regulation and how the team extended this work to long-read RNA sequencing of brain tissue, which enables isoform-level transcriptomic analysis alongside the genomic and epigenetic data.

Topics to be covered:
  • How a large-scale long-read whole-genome sequencing resource was built across multiple postmortem brain cohorts
  • How long reads reveal structural variants and repeat expansions linked to Alzheimer's disease and related dementias
  • What haplotype-specific methylation at loci such as APOE shows about epigenetic regulation that short reads can't reach
  • How long-read RNA sequencing adds isoform-resolved transcriptomic data to genomic and epigenetic analyses of the brain
  • An introduction to Oxford Nanopore by Walaa Mohamed
]]> Webinar Series SEQadmin2 https://www.seqanswers.com/forum/site-news/webinar-series/327704-decoding-the-genomics-of-neurodegeneration-with-large-scale-long-read-sequencing Spatial Transcriptomics and Metabolite Mapping Combined on a Single Tissue Slide https://www.seqanswers.com/forum/news/327703-spatial-transcriptomics-and-metabolite-mapping-combined-on-a-single-tissue-slide Tue, 29 Sep 2026 17:51:30 GMT Spatial transcriptomics (ST) shows which genes are active and where within a tissue, while spatial metabolomics (SM) maps the location of... Spatial transcriptomics (ST) shows which genes are active and where within a tissue, while spatial metabolomics (SM) maps the location of metabolites, the small molecules cells produce and use. A new open, low-cost imaging-based ST platform can now integrate SM on the same slide, addressing two problems that have limited the field: high cost and incompatibility between the two methods.

The platform, called OpenFISH, was described in a study led by Duan Lihui at the Institute of Genetics and Developmental Biology of the Chinese Academy of Sciences, published in Neuron. A biological system can be thought of as a multistory building, with information flowing from genome to transcripts to proteins to metabolites and finally to phenotype, and every layer interacting with the others. Measuring only one layer can miss the full picture and the connections between them. Existing ST technologies can detect molecular features within tissue at single-cell resolution, but they remain expensive and hard for many labs to use, and pairing imaging-based ST with the untargeted SM method MALDI-MSI on the same tissue section adds a further challenge.

To bring costs down, the researchers used a modular probe design along with a simple gene-coding system that removes the need for a microfluidic system, and they streamlined the experimental procedure so wet-lab time runs no more than 13 hours. A standard 20x widefield fluorescence microscope is enough to capture clear signals in situ. Together, these changes cut OpenFISH's total cost by about 95 percent compared with leading commercial platforms.

The team tested OpenFISH in two neuroscience applications: tracking cell-type-associated transposable element (TE) elevation during inflammation, and examining neuronal cell lamination distortion after knocking out the Reln gene. Reproducible TE upregulation pointed to TEs as active drivers or modulators of neuroinflammatory pathways, and beyond the known anatomical effects of Reln knockout, the researchers also found a decrease in D1-type inhibitory striatal neurons.

Because ST and SM are usually run on separate, adjacent tissue sections, differences between those sections can complicate interpretation. To combine both methods on one section, the researchers modified conductive glass slides for MALDI-MSI, using polyacrylamide gel embedding, protein digestion, and lipid removal so that OpenFISH signals remained detectable even after the harsh laser processing MALDI-MSI requires. Ion feature signals and transcript detection were barely affected by this integration, and the combined pipeline revealed cell-type-associated metabolites in mouse brain cells, with the merged modalities improving anatomical depiction.

Applied to 5xFAD mice, a model for Alzheimer's disease, the pipeline showed that microglia had the strongest changes, with multiple cell-type-associated metabolites elevated compared with healthy controls. The researchers describe the work as introducing a cost-effective ST tool that pairs with SM platforms to help untangle complex molecular interactions in biological systems.
]]> News SEQadmin2 https://www.seqanswers.com/forum/news/327703-spatial-transcriptomics-and-metabolite-mapping-combined-on-a-single-tissue-slide How Multiomics Methods are Advancing Disease Research https://www.seqanswers.com/forum/sequencing-technologies-companies/vendor-forum/327692-how-multiomics-methods-are-advancing-disease-research Fri, 25 Sep 2026 20:00:56 GMT Modern multiomics lets scientists explore the convergence of cellular identity, function, and modulation. That convergence, powered by data from...
Click image for larger version Name: digital-biotechnology-no-text_resize.jpg Views: 0 Size: 35.6 KB ID: 327695




Modern multiomics lets scientists explore the convergence of cellular identity, function, and modulation. That convergence, powered by data from multiple layers, is reshaping disease research. The ability to capture data from multiple omics, including the genome, epigenome, transcriptome, and proteome, is powered by technological advancement. New tools facilitate automated high-throughput library prep, help ensure qPCR reliability and reproducibility, and accelerate sequencing data analysis.



In this ebook, explore how automation, quantitative rigor, and AI-assisted interpretation are helping researchers turn multiomic complexity into a clearer picture of disease mechanisms. ]]> Sequencing Resources mdimapilis https://www.seqanswers.com/forum/sequencing-technologies-companies/vendor-forum/327692-how-multiomics-methods-are-advancing-disease-research Bat1K Consortium Combines Genomes and Fossils to Trace Bat Origins https://www.seqanswers.com/forum/news/327691-bat1k-consortium-combines-genomes-and-fossils-to-trace-bat-origins Fri, 25 Sep 2026 17:06:42 GMT An international consortium has sequenced and compared 103 bat genomes spanning all 21 recognized bat families, then combined that genomic dataset... An international consortium has sequenced and compared 103 bat genomes spanning all 21 recognized bat families, then combined that genomic dataset with information from 44 bat fossils to reconstruct how bats evolved their extraordinary biology. The study, led by researchers at the University of St Andrews as part of the Bat1K consortium, was published in Nature.

Bats make up roughly one in five mammal species and are the only mammals capable of powered flight, but their evolutionary history has been difficult to pin down using fossils or genetics alone. By sequencing genomes from across the full breadth of living bat diversity and integrating that data with the fossil record, the consortium built a more complete picture of bat evolution than either approach could produce on its own.

The genomic sequencing effort allowed the team to computationally reconstruct the ancestral bat genome, tracing the genetic changes that gave rise to traits such as echolocation and flight across the bat family tree. Comparing genomes across all 21 families also let researchers identify the genes and genetic changes associated with these specialized adaptations, linking specific sequence differences to the biological features that distinguish bat lineages from one another.

Combining this genomic resource with the fossil dataset gave the researchers a new way to date bat origins. According to Prof. Liliana M Dávalos, “The approach we used to model the evolution of fossil and living species together can do what other methods cannot: identify the oldest group of fossil bats while taking the genomic data into account, and uncover when and where bats originated.”

The scale of the genomic resource itself reflects years of coordinated sequencing work across the consortium. Prof. Sonja Vernes, who leads the Bat1K initiative, said, “Bats constantly surprise us. They are one of evolution’s greatest experiments. This extraordinary genomic resource, the culmination of years of international cooperation of Bat1K, is finally allowing us to understand how their remarkable biology evolved.”

By pairing whole-genome sequencing across the entire bat order with fossil-informed modeling, the study offers a genomic framework other researchers can use to investigate the molecular basis of bat-specific traits, and demonstrates how integrating large-scale comparative genomics with paleontological data can resolve evolutionary questions that neither dataset could answer alone.
]]> News SEQadmin2 https://www.seqanswers.com/forum/news/327691-bat1k-consortium-combines-genomes-and-fossils-to-trace-bat-origins <![CDATA[Postdoc Opportunities in RNA Directed Evolution: ERC Advanced Grant &quot;REVOLVER&quot;]]> https://www.seqanswers.com/forum/jobs-forums/academic-non-profit-jobs/327690-postdoc-opportunities-in-rna-directed-evolution-erc-advanced-grant-revolver Fri, 25 Sep 2026 08:31:11 GMT The Laboratory for Genomics of Long Noncoding RNA and Disease (GOLD Lab) is recruiting three postdoctoral researchers for a new ERC-funded programme... The Laboratory for Genomics of Long Noncoding RNA and Disease (GOLD Lab) is recruiting three postdoctoral researchers for a new ERC-funded programme applying directed evolution for the first time to long noncoding RNAs. The goal is to develop a deeper understanding of their molecular mechanisms and to engineer RNAs as a new class of therapeutic for liver disease.
You will lead your own research area within a diverse, well-resourced team, and develop expertise at the intersection of RNA, evolution, genome editing and translational medicine. The project benefits from a team of world leading international collaborators.
We are looking for ambitious, independent researchers with a PhD and strong track record in one or more of:
  • Directed evolution
  • Bio engineering
  • RNA biology
  • Genome editing
  • Computational genomics, evolutionary biology, fitness landscapes, or machine learning for biological sequences
Positions are fully funded for up to 5 years with competitive salary.
Start: March 2027 or soon after.
Location: University College Dublin, Ireland.
More about us: We at GOLD Lab love to study lncRNAs and exploit them for medicine. We employ an interdisciplinary wet/dry approach and develop new methods based on genome-editing. We work closely with leading international consortia and collaborators. Our core values are love of science, respect for each other, team work and rigorous thinking. See our website at https://gold-lab.org

To apply: Send a brief email outlining your relevant experience and motivation, telling us where you saw our advert, with attached CV, to rory.johnson@ucd.ie with subject line "REVOLVER PD". Applications will be accepted on a rolling basis until positions are filled (check our website).
]]> Academic/Non-Profit Jobs roryjohnson2 https://www.seqanswers.com/forum/jobs-forums/academic-non-profit-jobs/327690-postdoc-opportunities-in-rna-directed-evolution-erc-advanced-grant-revolver Microgravity Experiments Reveal Gravity’s Impact on Human Genome Organization https://www.seqanswers.com/forum/news/327689-microgravity-experiments-reveal-gravity’s-impact-on-human-genome-organization Wed, 23 Sep 2026 19:05:04 GMT The Human Genome Project, launched in 1990, eventually produced a full sequence of human DNA, but many of the physical rules governing how that... The Human Genome Project, launched in 1990, eventually produced a full sequence of human DNA, but many of the physical rules governing how that genome is organized inside cells remain unclear—including the influence of one force that’s present everywhere on Earth: gravity.

A new study in Science Advances tackles that question with an unusual approach: creating a zero-gravity, or microgravity, environment to study how a human cell’s genome behaves without gravity acting on it. The method serves two purposes at once—isolating gravity’s effect on the genome by removing it from the equation, and showing how the genome might function in the true zero-gravity conditions of outer space.

“On Earth, the role of gravity is intriguing—it is a constant mechanical stress on everything,” says NYU’s Alexandra Zidovska, who led the study. “We wanted to know what gravity’s role is in the genome’s organization and function here on Earth. To uncover it, you have to remove gravity as a force so we simulated zero gravity in our experiments.” The question matters beyond Earth too, she adds: “Beyond Earth, the question of lack of gravity is also compelling: How will the human genome be affected when in outer space? We think our findings can be useful in better understanding how space travel affects us.”

The human genome is packed with remarkable density—two meters of DNA folded into a cell nucleus roughly 10 micrometers across, about the width of a silk fiber. That structure is tightly linked to function, and disruptions to it are associated with diseases including cancer and developmental disorders, yet the physical principles behind the genome’s organization remain poorly understood. As Zidovska puts it, “We do not know if or how the presence of gravity affects this organization and if the absence of gravity would cause genomic aberrations.”

To investigate, the NYU team built a custom random positioning machine—similar in principle to devices used in astronaut training—that rotates dishes of live, bubble-free cells along two independent axes to simulate weightlessness. They also developed new rotational algorithms to minimize the fluid flows that rotation normally produces (but that don’t exist in true zero gravity), plus separate algorithms to study how those flows alone affect cells. Together, these advances reduced both flow effects and cell clumping that had obscured results in earlier studies of simulated microgravity.

After exposing cells to simulated microgravity, to strong flows, or to neither for 24 hours, the researchers used detailed imaging to track changes in cell and nuclear shape and volume, the nuclear envelope, the genome’s organization and movement, and the nucleolus. Cells exposed to flows became elongated, while cells in simulated microgravity kept their shape, though their nuclei grew larger—suggesting gravity normally helps keep the nucleus more compact. The nuclear envelope’s thickness and structure stayed unchanged in both conditions, and the genome held onto its normal organization and motion after the 24-hour exposure. Simulated microgravity did not cause DNA damage, but exposure to flows did, and the nucleolus became smoother under either condition. The researchers note that these subtle changes could compound over longer exposures and eventually affect cell physiology.

“Our data show that the genome, its organization, and dynamics are incredibly robust and seem unaffected by gravity, or lack thereof, after 24 hours,” Zidovska says. “In the same way, these results suggest that the physical organization of the human genome may undergo minimal changes in outer space during comparable times. However, such changes could occur during longer exposures and due to DNA damage occurring in space.”]]> News SEQadmin2 https://www.seqanswers.com/forum/news/327689-microgravity-experiments-reveal-gravity’s-impact-on-human-genome-organization Join the Live Webinar: Programming Biology with Genome-scale AI - 7th December - 3 PM CEST https://www.seqanswers.com/forum/bioinformatics/bioinformatics-aa/327688-join-the-live-webinar-programming-biology-with-genome-scale-ai-7th-december-3-pm-cest Tue, 22 Sep 2026 16:15:38 GMT Dear all, We are pleased to invite you to our upcoming live webinar, “Programming Biology with Genome-scale AI,” on 7 December 2026, from...
We are pleased to invite you to our upcoming live webinar, “Programming Biology with Genome-scale AI,” on 7 December 2026, from 3:00–5:00 PM (Berlin).



The webinar will explore DNA language models, genome-scale foundation models, AI-based variant interpretation, DNA design, and applications of AI in modern genomics and programmable biology.

The session will also include a live introduction to the Genomic Intelligence Platform and its applications in computational research workflows.



Date: 7 December 2026
Time: 3:00–5:00 PM (Berlin)
Format: Online via Zoom

Register here: https://www.physalia-courses.org/cou...ps/webinar-ai/



Best regards,



Carlo







--------------------

Carlo Pecoraro, Ph.D


Physalia-courses DIRECTOR]]> Bioinformatics Physalia-courses https://www.seqanswers.com/forum/bioinformatics/bioinformatics-aa/327688-join-the-live-webinar-programming-biology-with-genome-scale-ai-7th-december-3-pm-cest