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Hifiasm and sex chromosomes from XY specimen
I'm planning to do a pseudohaplotype assembly with Hifiasm on PacBio HiFi wgs data for an XY male specimen. Does anyone know how Hifiasm will handle the sex chromosomes? I mean, will it give me primary and alternate assemblies for the sex chromosomes? How will it handle the pseudoautosomal regions of homology between the X & Y? Is there a strategy I should be using to limit the mess I make of the sex chromosomes? I'm new to all of this, so pretend I'm 8 years old.
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Innovations in next-generation sequencing technologies and techniques are driving more precise and comprehensive exploration of complex biological systems. Current advancements include improved accessibility for long-read sequencing and significant progress in single-cell and 3D genomics. This article explores some of the most impactful developments in the field over the past year.
Long-Read Sequencing
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