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  • samtools mpileup questions

    I've got a question about using mpileup on multiple library data:

    is there any difference in variant calling between
    - run mpileup with multiple bam files as input,
    and
    - merge these bam files then run mpileup on the merged one

    Thanks much for your input.
    Last edited by go2seq; 07-02-2011, 01:56 PM.

  • #2
    Originally posted by go2seq View Post
    I've got a question about using mpileup on multiple library data:

    is there any difference in variant calling between
    - run mpileup with multiple bam files as input,
    and
    - merge these bam files then run mpileup on the merged one

    Thanks much for your input.
    I think using multiple bam files is much more faster

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