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I am also interested in this type of problem, did you find a software or method to detect this information about copy number changes? -
copy number changes from whole genome sequencing data
Hi:
Having whole genome sequence data for family, is it possible to identify copy number changes given bam or vcf files for all the family members. The sequencing data is aligned to hg19. I have the sequencing data for mother, father and affected and unaffected children.
I want to see if there are any gain or losses in affected child compared to other family members.
thanks
Adrian
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