Hi everyone, i got confused at the concept "transcripts" and "isoforms", in some paper they mentioned "transcripts", some paper mentioned "isoforms", some mentioned both, i thought they were the same, is that right? Sorry for this silly questions. Thank you very much!
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An isoform is specifically one of many splice variants of a gene, while a transcript is an expressed sequence. The difference is that "isoform" implies that there are multiple isoforms, while transcript makes no such implication. For example, prokaryote genes are mostly not spliced, so referring to them as isoforms generally does not make sense. For eukaryote genes with conditionally-used exons, referring to the individual expressed sequences as isoforms is useful.
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"The difference is that "isoform" implies that there are multiple isoforms, while transcript makes no such implication"
Hi Brian, As you mentioned, i think isoform means there are alternative splicing, is that right? and for transcript can i suppose the expressed transcript is an expressed gene if this transcript has no isoform?
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Originally posted by crayfish View Post"The difference is that "isoform" implies that there are multiple isoforms, while transcript makes no such implication"
Hi Brian, As you mentioned, i think isoform means there are alternative splicing, is that right? and for transcript can i suppose the expressed transcript is an expressed gene if this transcript has no isoform?
That said, some bioinformatics pipelines (eg trinity) will automatically pick both "genes" and "isoforms" and in this case, the program can refer to something as an "isoform" even if it has only picked one "isoform".Last edited by danwiththeplan; 04-29-2014, 08:47 PM.
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