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tools/approaches to detect mutated pathways

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  • tools/approaches to detect mutated pathways

    hi all,

    I have exome sequencing data of 50 patients. And my collaborator is specifically interested in a pathway including about 30 genes. I wonder if there is recommendation about the tool to detect significantly mutated (or malfunctioned) pathway(s).

    I am trying HotNet2. Any other suggestions?

    Thank you!

  • #2
    Dump your gene names into this ...

    https://david.ncifcrf.gov/

    "DAVID now provides a comprehensive set of functional annotation tools for investigators to understand biological meaning behind large list of genes."

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