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  • How to iterate GRanges objects in R for parallel processing more than one bed files?

    Hi:
    part of my job is to process bunch of bed files in parallel by using R. I have read each bed files as GRanges objects in R. I used GenomicRanges::findOverlaps(query, subjects) to observe overlapped peak regions. How can I efficiently iterate over each GRanges objects one by one with respect set of GRanges objects from second bed files.

    Here is my example to show genome interval:

    Code:
    GRanges object with 6 ranges and 2 metadata columns:
          seqnames           ranges strand |        name     score
             <Rle>        <IRanges>  <Rle> | <character> <numeric>
      [1]     chr1 [ 32727,  32817]      * | MACS_peak_1      8.69
      [2]     chr1 [ 52489,  52552]      * | MACS_peak_2      4.26
      [3]     chr1 [ 65527,  65590]      * | MACS_peak_3      4.19
      [4]     chr1 [ 65773,  65904]      * | MACS_peak_4      2.02
      [5]     chr1 [ 66001,  66117]      * | MACS_peak_5      5.66
      [6]     chr1 [115700, 115769]      * | MACS_peak_6     10.30
    overlap<- findOverlaps(bed.1[1], bed.2) # needs to update all GRanges object of bed.1;

    How can I do that ? Please help me out !!!
    Attached Files

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