CLC-Genomics - Version 6 apparently runs slower than V5

[NGS_New_User]

With a clear problem like this your first stop of inquiry should be CLC tech support. Is this a Mac or a PC? Are we talking about the same exact data set (in terms of size at least).

Thanks for the suggestion. I have just sent them an email, hopefully will get a response from them soon. It is a PC. Yes, the same exact data set

[GenoMax]

We have the same issue. CLC gwb version 5.5 was fast. We recently upgraded to version 6 and it was ok, but then after upgrading to version 6.0.3, it has become very slow. It freezes the whole computer, and takes almost 20 minutes to upload a file that only took 2 mins with version 5.

With a clear problem like this your first stop of inquiry should be CLC tech support. Is this a Mac or a PC? Are we talking about the same exact data set (in terms of size at least).

[NGS_New_User]

Same problem here, did you find solution?

The differences are by hours, infact twice the difference (~6 hours in 5.1 version and ~11 hours in Version 6) !

Both the computer use the same kind of structure and configuration, infact the slower mapping is in a system which is more powerful than the other computer.

Right now I am trying to download the legacy version (Version 5.1) in the same computer and would do a comparison between the versions within the same system.

We have the same issue. CLC gwb version 5.5 was fast. We recently upgraded to version 6 and it was ok, but then after upgrading to version 6.0.3, it has become very slow. It freezes the whole computer, and takes almost 20 minutes to upload a file that only took 2 mins with version 5.

Did you get a solution to the problem? I checked their website and there is a new version v6.0.4 for upgrade, have you tried this new upgrade?
Any info will be helpful, Thanks!

[Bucky]

For us it was the exact opposite: mapping in v5 took forever (much longer than in v4), but v6 was fast again (and still is). weird

[Bioanalyst]

The differences are by hours, infact twice the difference (~6 hours in 5.1 version and ~11 hours in Version 6) !

Both the computer use the same kind of structure and configuration, infact the slower mapping is in a system which is more powerful than the other computer.

Right now I am trying to download the legacy version (Version 5.1) in the same computer and would do a comparison between the versions within the same system.

[GenoMax]

What kind to difference are we talking about here? Minutes/hours?

Benchmarking software versions is something only the vendors probably care about, mainly for marketing purposes.

If you are convinced that this is an issue restricted to CLC version 6 (and not 5.x) then you may want to check in with CLC tech support.

[Bioanalyst]

Dear All, for some strange reasons, in our lab, we find CLC's latest version 6 runs slower than v5 for the same parameter of Reference based mapping. Version 6 in general claims to be much much faster than Version5...Anyone else facing similar issues?? any solution..shed some lights on it..