Originally posted by JuanLugo
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There is no essential difference between assembling a whole genome and a BAC, except the BAC is smaller, so achieving good coverage is easier, and the data set smaller. The need for paired data spanning the repeats and anchoring into unique sequence is the same in BAC and whole genome, and will be the limiting factor.
How 'good' do you want/need the result to be? There is a chance that a single lane of illumina (with barcoding) would do, but it depends on the answers to the above.
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