I want to check on the best approach that people have taken in analyzing sequencing data. I have exome sequence data for cases and controls and we want to find mutations that are in cases but not in controls. my first question is, do we use all the variants or just the one that passed all GATK filters?
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by seqadmin
The complexity of cancer is clearly demonstrated in the diverse ecosystem of the tumor microenvironment (TME). The TME is made up of numerous cell types and its development begins with the changes that happen during oncogenesis. “Genomic mutations, copy number changes, epigenetic alterations, and alternative gene expression occur to varying degrees within the affected tumor cells,” explained Andrea O’Hara, Ph.D., Strategic Technical Specialist at Azenta. “As...-
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07-08-2024, 03:19 PM -
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