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  • A Brief Overview and Common Challenges in Single-cell Sequencing Analysis

    A Brief Overview and Common Challenges in Single-cell Sequencing Analysis


    ​​​​​​The introduction of single-cell sequencing has advanced the ability to study cell-to-cell heterogeneity. Its use has improved our understanding of somatic mutations1, cell lineages2, cellular diversity and regulation3, and development in multicellular organisms4. Single-cell sequencing encompasses hundreds of techniques with different approaches to studying the genomes, transcriptomes, epigenomes, and other omics of individual cells. The analysis of single-cell sequencing data i...

    See more | Go to post

  • Introduction to Single-Cell Sequencing

    Introduction to Single-Cell Sequencing

    Single-cell sequencing is a technique used to investigate the genome, transcriptome, epigenome, and other omics of individual cells using high-throughput sequencing. This technology has provided many scientific breakthroughs and continues to be applied across many fields, including microbiology, oncology, immunology, neurobiology, precision medicine, and stem cell research.

    The advancement of single-cell sequencing began in 2009 when Tang et al. investigated the single-cell transcriptomes
    ...
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  • AVITI from Element Biosciences: Latest Sequencing Technologies—Part 6

    AVITI from Element Biosciences: Latest Sequencing Technologies—Part 6

    Element Biosciences made its sequencing market debut this year when it released AVITI, its first sequencer. The AVITI System uses avidity sequencing, a novel sequencing chemistry that delivers higher quality data, decreases cycle times, and requires lower reagent concentrations. This new instrument reportedly features lower operating and start-up costs while maintaining quality sequencing.

    Read type and length
    AVITI is a short-read benchtop sequencer that also offers an innovative...
    See more | Go to post

  • DNBSEQ-G400 from Complete Genomics: Latest Sequencing Technologies—Part 5

    DNBSEQ-G400 from Complete Genomics: Latest Sequencing Technologies—Part 5

    Complete Genomics (an MGI company) released the DNBSEQ-G400 into the U.S. market this summer. DNBSEQ-G400 is a benchtop sequencer that uses MGI’S DNA Nanoball sequencing technology (DNBSEQ) that boasts low index hopping, low amplification bias, and low PCR amplification error accumulation. In addition, the instrument is capable of using an improved antibody-based chemistry, CoolMPS sequencing reagent, that reduces errors and improves the sequencing quality.

    Read type and length...
    See more | Go to post

  • Onso from Pacific Biosciences: Latest Sequencing Technologies—Part 4

    Onso from Pacific Biosciences: Latest Sequencing Technologies—Part 4

    Onso was the second sequencer Pacific Biosciences (PacBio) revealed during this year’s American Society of Human Genetics meeting (read about the first sequencer here). This benchtop sequencer uses sequencing by binding (SBB), a method unlike any other instrument on the market. SBB incorporates native nucleotides, has reduced molecular scarring, and reportedly results in significantly higher accuracy base calls than traditional short-read sequencers. The following sections highlight the important...
    See more | Go to post

  • Revio from Pacific Biosciences: Latest Sequencing Technologies—Part 3

    Revio from Pacific Biosciences: Latest Sequencing Technologies—Part 3

    Pacific Biosciences (PacBio) revealed two new sequencers during this year’s American Society of Human Genetics meeting. The first instrument, Revio, which will be covered in this article, is a significant upgrade from their previous Sequel II device. It has lower costs, shorter run times, more SMRT Cells and zero-mode waveguides (ZMW), and significantly higher output compared to PacBio’s other sequencers.

    Read type and length
    As a part of PacBio’s long-read sequencing systems,...
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  • PromethION 2 Solo from Oxford Nanopore: Latest Sequencing Technologies—Part 2

    PromethION 2 Solo from Oxford Nanopore: Latest Sequencing Technologies—Part 2

    There has been a flurry of activity among next-gen sequencing companies this year with a number of new sequencers being announced. In October, Oxford Nanopore Technologies (ONT) announced the release of their new device, the PromethION 2 (P2) Solo sequencer. The P2 Solo is a small, high-yield sequencer with considerably lower starting costs compared to some of its competitors; the starter pack for ONT’s latest device is priced around $10,455. Despite its small size, the P2 Solo stands as a valuable...
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  • NovaSeq X and X Plus from Illumina: Latest Sequencing Technologies—Part 1

    NovaSeq X and X Plus from Illumina: Latest Sequencing Technologies—Part 1

    In the Fall of 2022 Illumina announced their newest pair of flagship sequencers: the NovaSeq X and the NovaSeq X Plus. Their development was part of Illumina’s pursuit of lowering the cost of sequencing by dropping the price to approximately $200 per genome. The major differences between Illumina’s previous top sequencer (the NovaSeq 6000) and the NovaSeq X and X Plus are that the new devices have more affordable and updated reagents, faster run times, and the ability to process data directly...
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  • A Brief Overview and Common Challenges in Single-cell Sequencing Analysis
    by seqadmin


    ​​​​​​The introduction of single-cell sequencing has advanced the ability to study cell-to-cell heterogeneity. Its use has improved our understanding of somatic mutations1, cell lineages2, cellular diversity and regulation3, and development in multicellular organisms4. Single-cell sequencing encompasses hundreds of techniques with different approaches to studying the genomes, transcriptomes, epigenomes, and other omics of individual cells. The analysis of single-cell sequencing data i...

    01-24-2023, 01:19 PM
  • Introduction to Single-Cell Sequencing
    by seqadmin
    Single-cell sequencing is a technique used to investigate the genome, transcriptome, epigenome, and other omics of individual cells using high-throughput sequencing. This technology has provided many scientific breakthroughs and continues to be applied across many fields, including microbiology, oncology, immunology, neurobiology, precision medicine, and stem cell research.

    The advancement of single-cell sequencing began in 2009 when Tang et al. investigated the single-cell transcriptomes
    ...
    01-09-2023, 03:10 PM
  • AVITI from Element Biosciences: Latest Sequencing Technologies—Part 6
    by seqadmin
    Element Biosciences made its sequencing market debut this year when it released AVITI, its first sequencer. The AVITI System uses avidity sequencing, a novel sequencing chemistry that delivers higher quality data, decreases cycle times, and requires lower reagent concentrations. This new instrument reportedly features lower operating and start-up costs while maintaining quality sequencing.

    Read type and length
    AVITI is a short-read benchtop sequencer that also offers an innovative...
    12-29-2022, 10:44 AM
  • DNBSEQ-G400 from Complete Genomics: Latest Sequencing Technologies—Part 5
    by seqadmin
    Complete Genomics (an MGI company) released the DNBSEQ-G400 into the U.S. market this summer. DNBSEQ-G400 is a benchtop sequencer that uses MGI’S DNA Nanoball sequencing technology (DNBSEQ) that boasts low index hopping, low amplification bias, and low PCR amplification error accumulation. In addition, the instrument is capable of using an improved antibody-based chemistry, CoolMPS sequencing reagent, that reduces errors and improves the sequencing quality.

    Read type and length...
    12-21-2022, 12:39 PM
  • Onso from Pacific Biosciences: Latest Sequencing Technologies—Part 4
    by seqadmin
    Onso was the second sequencer Pacific Biosciences (PacBio) revealed during this year’s American Society of Human Genetics meeting (read about the first sequencer here). This benchtop sequencer uses sequencing by binding (SBB), a method unlike any other instrument on the market. SBB incorporates native nucleotides, has reduced molecular scarring, and reportedly results in significantly higher accuracy base calls than traditional short-read sequencers. The following sections highlight the important...
    12-19-2022, 10:32 AM
  • Revio from Pacific Biosciences: Latest Sequencing Technologies—Part 3
    by seqadmin
    Pacific Biosciences (PacBio) revealed two new sequencers during this year’s American Society of Human Genetics meeting. The first instrument, Revio, which will be covered in this article, is a significant upgrade from their previous Sequel II device. It has lower costs, shorter run times, more SMRT Cells and zero-mode waveguides (ZMW), and significantly higher output compared to PacBio’s other sequencers.

    Read type and length
    As a part of PacBio’s long-read sequencing systems,...
    12-14-2022, 09:32 AM
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