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  Non-Coding RNA Research and Technologies

  • Published: Today, 08:07 AM
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  Non-Coding RNA Research and Technologies

  
  
  Non-coding RNAs (ncRNAs) do not code for proteins but play important roles in numerous cellular processes including gene silencing, developmental pathways, and more. There are numerous types including microRNA (miRNA), long ncRNA (lncRNA), circular RNA (circRNA), and more. In this article, we discuss innovative ncRNA research and explore recent technological advancements that improve the study of ncRNAs.
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  [Article Coming Soon!]...

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  Recent Developments in Metagenomics

  • Published: 09-23-2024, 06:35 AM
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  Recent Developments in Metagenomics

  
  
  
  
  
  Metagenomics has improved the way researchers study microorganisms across diverse environments. Historically, studying microorganisms relied on culturing them in the lab, a method that limits the investigation of many species since most are unculturable¹. Metagenomics overcomes these issues by allowing the study of microorganisms regardless of their ability to be cultured or the environments they inhabit. Over time, the field has evolved, especially with the advent...

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  Understanding Genetic Influence on Infectious Disease

  • Published: 09-09-2024, 10:59 AM
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  Understanding Genetic Influence on Infectious Disease

  
  
  
  
  During the COVID-19 pandemic, scientists observed that while some individuals experienced severe illness when infected with SARS-CoV-2, others were barely affected. These disparities left researchers and clinicians wondering what causes the wide variations in response to viral infections and what role genetics plays.
  
  Jean-Laurent Casanova, M.D., Ph.D., Professor at Rockefeller University, is a leading expert in this crossover between genetics and infectious...

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  Addressing Off-Target Effects in CRISPR Technologies

  • Published: 08-27-2024, 04:44 AM
  • 221 views
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  Addressing Off-Target Effects in CRISPR Technologies

  
  
  
  
  
  
  The first FDA-approved CRISPR-based therapy marked the transition of therapeutic gene editing from a dream to reality¹. CRISPR technologies have streamlined gene editing, and CRISPR screens have become an important approach for identifying genes involved in disease processes². This technique introduces targeted mutations across numerous genes, enabling large-scale identification of gene functions, interactions, and pathways³. Identifying the full range...

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  Selecting and Optimizing mRNA Library Preparations

  • Published: 08-07-2024, 12:11 PM
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  Selecting and Optimizing mRNA Library Preparations

  
  
  
  
  Sequencing mRNA provides a snapshot of cellular activity, allowing researchers to study the dynamics of cellular processes, compare gene expression across different tissue types, and gain insights into the mechanisms of complex diseases. “mRNA’s central role in the dogma of molecular biology makes it a logical and relevant focus for transcriptomic studies,” stated Sebastian Aguilar Pierlé, Ph.D., Application Development Lead at Inorevia. “One of the major hurdles...

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  Exploring the Dynamics of the Tumor Microenvironment

  • Published: 07-08-2024, 03:19 PM
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  Exploring the Dynamics of the Tumor Microenvironment

  
  
  
  
  The complexity of cancer is clearly demonstrated in the diverse ecosystem of the tumor microenvironment (TME). The TME is made up of numerous cell types and its development begins with the changes that happen during oncogenesis. “Genomic mutations, copy number changes, epigenetic alterations, and alternative gene expression occur to varying degrees within the affected tumor cells,” explained Andrea O’Hara, Ph.D., Strategic Technical Specialist at Azenta. “As...

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  Exploring Human Diversity Through Large-Scale Omics

  • Published: 06-25-2024, 06:43 AM
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  Exploring Human Diversity Through Large-Scale Omics

  
  
  
  In 2003, researchers from the Human Genome Project (HGP) announced the most comprehensive genome to date¹. Although the genome wasn’t fully completed until nearly 20 years later², numerous large-scale projects, such as the International HapMap Project and 1000 Genomes Project, continued the HGP's work, capturing extensive variation and genomic diversity within humans. Recently, newer initiatives have significantly increased in scale and expanded beyond genomics, offering a...

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  Best Practices for Single-Cell Sequencing Analysis

  • Published: 06-06-2024, 07:15 AM
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  Best Practices for Single-Cell Sequencing Analysis

  
  
  
  
  While isolating and preparing single cells for sequencing was historically the bottleneck, recent technological advancements have shifted the challenge to data analysis. This highlights the rapidly evolving nature of single-cell sequencing. The inherent complexity of single-cell analysis has intensified with the surge in data volume and the incorporation of diverse and more complex datasets. This article explores the challenges in analysis, examines common pitfalls,...

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  Latest Developments in Precision Medicine

  • Published: 05-24-2024, 01:16 PM
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  Latest Developments in Precision Medicine

  
  
  
  
  
  Technological advances have led to drastic improvements in the field of precision medicine, enabling more personalized approaches to treatment. This article explores four leading groups that are overcoming many of the challenges of genomic profiling and precision medicine through their innovative platforms and technologies.
  
  Somatic Genomics
  “We have such a tremendous amount of genetic diversity that exists within each of us, and not just between...

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  Recent Advances in Sequencing Analysis Tools

  • Published: 05-06-2024, 07:48 AM
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  Recent Advances in Sequencing Analysis Tools

  
  
  
  The sequencing world is rapidly changing due to declining costs, enhanced accuracies, and the advent of newer, cutting-edge instruments. Equally important to these developments are improvements in sequencing analysis, a process that converts vast amounts of raw data into a comprehensible and meaningful form. This complex task requires expertise and the right analysis tools. In this article, we highlight the progress and innovation in sequencing analysis by reviewing several...

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