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  • inGAP-sv: a new tool to identify and visualize structural variations

    We have developed a tool to identify and visualize structural variations (SVs) from paired-end mapping data.

    It has a few advantages compared with other similar tools.
    1. It can detect large insertions and complex SVs.
    2. It employs a new scoring system to evaluate the quality of predicted SVs.
    3. It can distinguish heterozygous and homozygous SVs.
    4. It can effectively filter false positives, particularly those associated with tandem repeats.
    5. It provides a user-friendly graphic interface to detect, verify, annotate, and manually edit SVs.

    The tool can be downloaded from http://ingap.sourceforge.net/
    A quick manual can be accessed at http://schuster-33.bx.psu.edu/shared/manual.pdf

Latest Articles

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  • seqadmin
    Current Approaches to Protein Sequencing
    by seqadmin


    Proteins are often described as the workhorses of the cell, and identifying their sequences is key to understanding their role in biological processes and disease. Currently, the most common technique used to determine protein sequences is mass spectrometry. While still a valuable tool, mass spectrometry faces several limitations and requires a highly experienced scientist familiar with the equipment to operate it. Additionally, other proteomic methods, like affinity assays, are constrained...
    04-04-2024, 04:25 PM
  • seqadmin
    Strategies for Sequencing Challenging Samples
    by seqadmin


    Despite advancements in sequencing platforms and related sample preparation technologies, certain sample types continue to present significant challenges that can compromise sequencing results. Pedro Echave, Senior Manager of the Global Business Segment at Revvity, explained that the success of a sequencing experiment ultimately depends on the amount and integrity of the nucleic acid template (RNA or DNA) obtained from a sample. “The better the quality of the nucleic acid isolated...
    03-22-2024, 06:39 AM

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