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Frequency of CXCR4-using viruses in primary HIV-1 infections using ultra-deep pyrosequencing.
AIDS. 2011 Jun 13;
Authors: Raymond S, Saliou A, Nicot F, Delobel P, Dubois M, Cazabat M, Sandres-Sauné K, Marchou B, Massip P, Izopet J
We used ultra-deep pyrosequencing and the TTT phenotypic assay to determine the prevalence of CXCR4-using viruses in 21 patients with primary HIV-1 infections. We found X4-containing virus populations in 9% of patients by ultra-deep pyrosequencing using PSSMX4/R5 or geno2pheno5.75 and in 14% using the combined 11/25 and net charge rule. The phenotypic assay identified 9% of CXCR4-using viruses. This confirms that R5 viruses are predominant in primary HIV-1 infections.
PMID: 21673557 [PubMed - as supplied by publisher]
More...
Frequency of CXCR4-using viruses in primary HIV-1 infections using ultra-deep pyrosequencing.
AIDS. 2011 Jun 13;
Authors: Raymond S, Saliou A, Nicot F, Delobel P, Dubois M, Cazabat M, Sandres-Sauné K, Marchou B, Massip P, Izopet J
We used ultra-deep pyrosequencing and the TTT phenotypic assay to determine the prevalence of CXCR4-using viruses in 21 patients with primary HIV-1 infections. We found X4-containing virus populations in 9% of patients by ultra-deep pyrosequencing using PSSMX4/R5 or geno2pheno5.75 and in 14% using the combined 11/25 and net charge rule. The phenotypic assay identified 9% of CXCR4-using viruses. This confirms that R5 viruses are predominant in primary HIV-1 infections.
PMID: 21673557 [PubMed - as supplied by publisher]
More...