Epigenetics research has played a valuable role in understanding different components of various diseases and disorders, and utilizing the proper tools and methods is vital. “The method of choice to analyze epigenetic modifications and their role in diseases is dependent on the epigenetics platform to be investigated,” explained Said Goueli, Senior Research Fellow at Promega. As reviewed in our recent articles, there are many important methods for epigenetic profiling. Using many...
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Epigenetics and Disease: Research for Improving Human Health
Epigenetics research has played a valuable role in understanding different components of various diseases and disorders, and utilizing the proper tools and methods is vital. “The method of choice to analyze epigenetic modifications and their role in diseases is dependent on the epigenetics platform to be investigated,” explained Said Goueli, Senior Research Fellow at Promega. As reviewed in our recent articles, there are many important methods for epigenetic profiling. Using many... -
A Review of Next-Generation Sequencing Methods for Studying Epigenetics—Part 2
In the first segment of our review of epigenetic sequencing methods, we covered methylation detection, chromatin accessibility, and protein-DNA interactions. This final part of our review will break outside of the standard analysis and cover some influential multidimensional methods.
Spatial Epigenomics
“Epigenetic assays, whether conducted at the single-cell or bulk level, have played a crucial role in unraveling the underlying mechanisms of diseases and...