Would the stability of the transcriptome be affected by factors such as pathological conditions，physical activity, diet?

[William007]

Hi all, We plan to conduct a population-based study with the main method being transcriptomic analysis of human peripheral blood.

Would the stability of the transcriptome be affected by factors such as physical activity, diet, pathological conditions, and environmental factors?

If this is indeed the case, are there any feasible solutions available?
If this problem cannot be resolved, is it even necessary to conduct transcriptomic analysis?

Are there any omics fields, such as genomics, transcriptomics, metabolomics, epigenomics, proteomics, gut microbiomics, single-cell omics, immunomics, and peptidomics, that may be less influenced by factors such as physical activity, diet, pathological conditions, environmental factors, among others?

Thanks!