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Sample Prep / Library Generation
Techniques and protocol discussions on sample preparation, library generation, methods and ideas
Topics: 2,200
Posts: 9,922
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2,200 | 9,922 |
by dasi
03-12-2026, 08:38 AM
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Single Cell Sequencing
Techniques, discussions, and applications of single cell sequencing.
Topics: 8
Posts: 15
Last Post:
Reference mapping for scRNA seq data?
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8 | 15 |
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Genomic Resequencing
Variant discovery in previously sequenced genomes/regions
Topics: 280
Posts: 994
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280 | 994 |
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De novo discovery
Wandering without a reference? Post here
Topics: 340
Posts: 1,699
Last Post:
Hifiasm and sex chromosomes from XY specimen
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340 | 1,699 |
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Metagenomics
Ever wonder what's growing in that hot spring or glacier?
Topics: 268
Posts: 847
Last Post:
Impact of biomass on shotgun sequencing
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268 | 847 |
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Epigenetics
Any non-primary sequence heritable modification of genetic material. ChIP-SEQ, DNA methylation (Bisulfite-SEQ), chromatin modifications (methylation, acetylation, etc), non coding RNA.
Topics: 357
Posts: 1,578
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357 | 1,578 | |
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RNA Sequencing
Application of sequencing to RNA analysis (RNA-Seq, whole transcriptome, SAGE, expression analysis, novel organism mining, splice variants)
Topics: 2,865
Posts: 11,429
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2,865 | 11,429 |
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Clinical Sequencing
Discuss issues unique to clinical sequencing.
Topics: 38
Posts: 104
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38 | 104 |
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Next-generation sequencing (NGS) is now central to outbreak investigations and antimicrobial resistance tracking. Through sophisticated...07-31-2026, 07:00 AM
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CRISPR/Cas9 sparked the gene editing revolution for both research and therapeutics.1 But this system still showed severe issues that limited its applications. The most prominent were the heavy reliance on PAM sequences, delivery limitations, double-stranded breaks that prompt unintended edits and cell death, and editing inefficiency (both in targeting and in knock-in reliability).
Despite this, “CRISPR helped turn genome editing from a specialized technique into...07-31-2026, 11:01 AM -
Proteomics platforms are evolving rapidly, with advances in mass spectrometry and affinity-based approaches expanding what researchers can detect and at what scale. As the field moves toward deeper proteome coverage and clinical applications, scientists face an increasingly complex landscape of tools. This article will explore how researchers are navigating these choices to find the right platform for their work.
The systematic characterization of the human proteome has...07-20-2026, 11:48 AM -
Genomics studies in neuroscience face a special challenge due to the brain’s complexity and scarcity of samples. Mapping changes in cell type and state using conventional next-generation sequencing methods remains challenging. Advances in technologies like single-cell sequencing, spatial transcriptomics, and long-read sequencing have opened the door to deeper studies of the brain and diseases like Alzheimer’s, amyotrophic lateral sclerosis (ALS), and schizophrenia.
...07-09-2026, 11:10 AM