Seqanswers Leaderboard Ad

Collapse

Announcement

Collapse
No announcement yet.
X
 
  • Filter
  • Time
  • Show
Clear All
new posts

  • yinshe
    replied
    Thanks for the information. I also post this question to GATK community, and there is an extensive discussion on this topic. And here is the link:

    Leave a comment:


  • Richard Finney
    replied
    Check this thread : http://seqanswers.com/forums/showthread.php?t=9354

    Leave a comment:


  • yinshe
    started a topic strand bias variant call

    strand bias variant call

    We found some heterzygous calls. When we checked in IGV, the reads with reference base are balanced between plus strand and minus strand, however, the reads with alternative base are only mapped to minus strand or plus strand. In which way the reads with alternative base can be so biased? The mapping quality are OK for these reads.

    It could be alternative allele only be sequenced on one strand but for reference allele, both strand are sequenced. Is it possible like this if the experiment is not designed so?

    Or, these alternative alleles are artifacts. But what could be the reasons to generate these artifacts?

    Thanks for any feedback/discussion.

Latest Articles

Collapse

  • seqadmin
    Latest Developments in Precision Medicine
    by seqadmin



    Technological advances have led to drastic improvements in the field of precision medicine, enabling more personalized approaches to treatment. This article explores four leading groups that are overcoming many of the challenges of genomic profiling and precision medicine through their innovative platforms and technologies.

    Somatic Genomics
    “We have such a tremendous amount of genetic diversity that exists within each of us, and not just between us as individuals,”...
    Yesterday, 01:16 PM
  • seqadmin
    Recent Advances in Sequencing Analysis Tools
    by seqadmin


    The sequencing world is rapidly changing due to declining costs, enhanced accuracies, and the advent of newer, cutting-edge instruments. Equally important to these developments are improvements in sequencing analysis, a process that converts vast amounts of raw data into a comprehensible and meaningful form. This complex task requires expertise and the right analysis tools. In this article, we highlight the progress and innovation in sequencing analysis by reviewing several of the...
    05-06-2024, 07:48 AM

ad_right_rmr

Collapse

News

Collapse

Topics Statistics Last Post
Started by seqadmin, Yesterday, 07:15 AM
0 responses
13 views
0 likes
Last Post seqadmin  
Started by seqadmin, 05-23-2024, 10:28 AM
0 responses
17 views
0 likes
Last Post seqadmin  
Started by seqadmin, 05-23-2024, 07:35 AM
0 responses
20 views
0 likes
Last Post seqadmin  
Started by seqadmin, 05-22-2024, 02:06 PM
0 responses
10 views
0 likes
Last Post seqadmin  
Working...
X