VCF to MAF (Mutation Annotation Format)?

[kasthuri]

Can anybody point me to a tool that can convert a vcf file to Mutation Annotation Format (MAF) file?

That will be great!

Thanks
-Kasthuri

[gormleymp]

Convert Variant Call Format to Mutation Annotation Format

I am also looking for a tool to convert variant call format files (.vcf) to mutation annotation format files.

There is a python script vcf2maf available on github but this code looks for specific fields in the vcf header that are unique to TCGA .vcf files. When I run this code on my data it errors out due to missing fields.

Thanks,
Mike

[Gesseca]

vcf to maf

I am also looking for a tool that will do this, and I was wondering how people usually generate MAF files? Don't you usually need the original alignments (BAM files)?

I am working with data where I was only given the vcf file and I dont' know if it's possible to generate MAF without bam files or original alignment files.

Anybody know?

[m_two]

Convert VCF (Variant Call Format) into TCGA MAF (Mutation Annotation Format)


github.com/cbare/vcf2maf

Read in a vcf file outputted by SNPEff. Parse and output the data in tcga maf format

code.google.com/p/ngs-analysis/source/browse/modules/somatic/vcf2maf.py

Same question here: www.biostars.org/p/74822/

[Gesseca]

I have heard of this script, but I heard that it only works on very specific input.

[id0]

I was trying to use Oncotator, which takes MAF file as input. What I ended up doing is simply extracting the relevant columns from a VCF file and arranging them in the correct order.

cat file.vcf | \
awk -F $'\t' 'BEGIN {OFS=FS} {print $1,$2,$2,$4,$5,"","hg19"}' | \
sed 's/,\([ACGT]\)\t/\t\1/g' | \
grep -v "#" | \
awk 'NR==1{print "Chromosome\tStart_Position\tEnd_Position\tReference_Allele\tTumor_Seq_Allele1\tTumor_Seq_Allele2\tNCBI_Build"}1' \
> file.maf

It's not perfect, but for the purpose of Oncotator, this was sufficient.