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  • Help with Cosmic

    Hi I am new to the forum and need help. I am trying to search for the breakpoints of common cancer translocations in Cosmic, for example the common PAX8-PPARG or RET-PTC fusions.

    I have downloaded a number of their databases (Structural, Fusion, Mutant, etc) and have failed to find these common gene rerrangements listed in any of them.

    I have then tried searching their web interface for something as simple as "PAX8" and these widely reported translocations do not show up in their results. The same goes for RET-PTC (a rearrangement with numerous genes such as RET-CCDC6 & RET-PRKAR1A).

    Yet, when I look at Cosmic news, I can see beautiful web graphic of other gene translocations that do no interest me in the least. See link below. I simply want to find the genomic location (estimated breakpoint) of a selected group of mutant genes such as those I listed above. Can you help me figure out how to search for this information?

    Thank you so much!

    COSMIC, the Catalogue Of Somatic Mutations In Cancer, is the world's largest and most comprehensive resource for exploring the impact of somatic mutations in human cancer.

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