1. when predicting nsSNV, how can the tools recognize the reference sequence? the reference file in program or input sequence i gave?
i'm doing research about normal-tumor cancer sequence comparison,
and i'm planning to input normal base as reference and tumor base as input data at each position where i'm interested in.
2. is there any other good idea or tools for analyzing Normal-Tumor pair sequence?
HELP!!!! please
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The complexity of cancer is clearly demonstrated in the diverse ecosystem of the tumor microenvironment (TME). The TME is made up of numerous cell types and its development begins with the changes that happen during oncogenesis. “Genomic mutations, copy number changes, epigenetic alterations, and alternative gene expression occur to varying degrees within the affected tumor cells,” explained Andrea O’Hara, Ph.D., Strategic Technical Specialist at Azenta. “As...07-08-2024, 03:19 PM