I have a kind of basic question- I have a SE chipseq data for histone modification, Do we need to a specific wet lab experiment before we run NPS alogrithm for checking nucleosome positioning. The data I have is from regular chipseq and is not specifically from nucleosome fraction. My idea is to overlay the histone modification regions with nucleosome positioning. Any suggestion or feedback please.
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The complexity of cancer is clearly demonstrated in the diverse ecosystem of the tumor microenvironment (TME). The TME is made up of numerous cell types and its development begins with the changes that happen during oncogenesis. “Genomic mutations, copy number changes, epigenetic alterations, and alternative gene expression occur to varying degrees within the affected tumor cells,” explained Andrea O’Hara, Ph.D., Strategic Technical Specialist at Azenta. “As...-
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