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If you're just browsing the human genome sequence you may get a false impression of the content of Ns since there are huge streches of poly-N at both the telomeres and centromeres of every chromosome. These regions are particularly repetitive and almost impossible to assemble. The Ns on the end are just there so that the overall chromosome length shown is roughly correct.
Other than that internal Ns are now relatively infrequent and generally represent short, highly repetitive regions.
Compared to the assemblies of a lot of other vertebrate species though the human genome is very complete and accurate!
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by seqadmin
The field of epigenetics has traditionally concentrated more on DNA and how changes like methylation and phosphorylation of histones impact gene expression and regulation. However, our increased understanding of RNA modifications and their importance in cellular processes has led to a rise in epitranscriptomics research. “Epitranscriptomics brings together the concepts of epigenetics and gene expression,” explained Adrien Leger, PhD, Principal Research Scientist...-
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04-22-2024, 07:01 AM -
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by seqadmin
Proteins are often described as the workhorses of the cell, and identifying their sequences is key to understanding their role in biological processes and disease. Currently, the most common technique used to determine protein sequences is mass spectrometry. While still a valuable tool, mass spectrometry faces several limitations and requires a highly experienced scientist familiar with the equipment to operate it. Additionally, other proteomic methods, like affinity assays, are constrained...-
Channel: Articles
04-04-2024, 04:25 PM -
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