Who can tell me, please!
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Repeats that could not be assembled, regions that could not be cloned, and a lot of other reasons. I would review the original human genome project paper for more details.Originally posted by houhuabin View Post -
there are some gaps (are represented in Ns)Comment
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If you're just browsing the human genome sequence you may get a false impression of the content of Ns since there are huge streches of poly-N at both the telomeres and centromeres of every chromosome. These regions are particularly repetitive and almost impossible to assemble. The Ns on the end are just there so that the overall chromosome length shown is roughly correct.
Other than that internal Ns are now relatively infrequent and generally represent short, highly repetitive regions.
Compared to the assemblies of a lot of other vertebrate species though the human genome is very complete and accurate!Comment
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Tumors contain complex mixtures of cell populations that evolve in response to treatment and host-specific factors. Tissue biopsies provide only static snapshots of a tumor’s state. But what if we could follow that evolution over time using a minimally invasive technique?
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