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  • lher
    started a topic sequence bias correction in base coverage calculation

    sequence bias correction in base coverage calculation

    Hi,

    I have 76 bp Illumina HiSeq yeast mRNA seq data and would like to do a combined analysis of sequence coverage over a set of ~500 transcripts, which are all aligned in a range from 1 to 1000.
    However, the combined coverage profile is still noisy and shows many artificial peaks.
    Is there a way to account for sequencing biases and then modify the genome coverage file (e.g. bedgraph) respectively?

    Thanks for any suggestions!

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  • seqadmin
    Multiomics Techniques Advancing Disease Research
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    New and advanced multiomics tools and technologies have opened new avenues of research and markedly enhanced various disciplines such as disease research and precision medicine1. The practice of merging diverse data from various ‘omes increasingly provides a more holistic understanding of biological systems. As Maddison Masaeli, Co-Founder and CEO at Deepcell, aptly noted, “You can't explain biology in its complex form with one modality.”

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    02-08-2024, 06:33 AM

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