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  • swNGS
    replied
    small, multiple repeats of the same experiment generating a few 100's variants per sample, approx a dozen samples at a time. I would however be interested in something that can scale up to exome-sized vcfs

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  • xied75
    replied
    How big is your dataset? What if you can't hold them in one physical machine? You'll scale-up or scale-out?

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  • swNGS
    replied
    I'm in the process of doing something similar, and rather than reinventing the wheel, am looking into adapting ensembl's variant database as a means of storing vcfs derived from many similar targeted sequencing projects. It's based on a MySQL database and you can get the database structure from ENSEMBL with fairly comprehensive instructions. The attraction is that they have a set of scripts that, for example automate the import process amongst other things

    If anyone has any solutions to store e contents of vcf files in a database structure, I would be interested to hear about it too

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  • DataDiviner
    started a topic VCF Database

    VCF Database

    Hi all, I am looking into a DBMS for database storage. We have analyzed VCF Files.

    1000genomes.org is your first and best source for all of the information you’re looking for. From general topics to more of what you would expect to find here, 1000genomes.org has it all. We hope you find what you are searching for!


    When I say analyzed I mean data that has been aligned with some other steps but is still in a VCF format.

    My question is does anyone have any experience with good database systems? Our problem is when you choose an indexing you may be indexing for one question and when you go to ask a different question your query may not be optimized for the next question. We are looking at systems such as Key/Value, RDBMS, Graph, and BigTable. I only have experience with RDBMS systems would be interested in hearing any and all experience on this problem. Thanks!

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  • seqadmin
    Recent Advances in Sequencing Analysis Tools
    by seqadmin


    The sequencing world is rapidly changing due to declining costs, enhanced accuracies, and the advent of newer, cutting-edge instruments. Equally important to these developments are improvements in sequencing analysis, a process that converts vast amounts of raw data into a comprehensible and meaningful form. This complex task requires expertise and the right analysis tools. In this article, we highlight the progress and innovation in sequencing analysis by reviewing several of the...
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