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small, multiple repeats of the same experiment generating a few 100's variants per sample, approx a dozen samples at a time. I would however be interested in something that can scale up to exome-sized vcfs
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How big is your dataset? What if you can't hold them in one physical machine? You'll scale-up or scale-out?
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I'm in the process of doing something similar, and rather than reinventing the wheel, am looking into adapting ensembl's variant database as a means of storing vcfs derived from many similar targeted sequencing projects. It's based on a MySQL database and you can get the database structure from ENSEMBL with fairly comprehensive instructions. The attraction is that they have a set of scripts that, for example automate the import process amongst other things
If anyone has any solutions to store e contents of vcf files in a database structure, I would be interested to hear about it too
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VCF Database
Hi all, I am looking into a DBMS for database storage. We have analyzed VCF Files.
1000genomes.org is your first and best source for all of the information you’re looking for. From general topics to more of what you would expect to find here, 1000genomes.org has it all. We hope you find what you are searching for!
When I say analyzed I mean data that has been aligned with some other steps but is still in a VCF format.
My question is does anyone have any experience with good database systems? Our problem is when you choose an indexing you may be indexing for one question and when you go to ask a different question your query may not be optimized for the next question. We are looking at systems such as Key/Value, RDBMS, Graph, and BigTable. I only have experience with RDBMS systems would be interested in hearing any and all experience on this problem. Thanks!
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The complexity of cancer is clearly demonstrated in the diverse ecosystem of the tumor microenvironment (TME). The TME is made up of numerous cell types and its development begins with the changes that happen during oncogenesis. “Genomic mutations, copy number changes, epigenetic alterations, and alternative gene expression occur to varying degrees within the affected tumor cells,” explained Andrea O’Hara, Ph.D., Strategic Technical Specialist at Azenta. “As...-
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