Hi, I'm an undergratuated student in msc Biostatistics in France, and I'm stuck with DGE data.
I'd like to compare multiple DGE librairies without replicates. I got 4 librairies that describe 4 different conditions (Young Males/Females , Old Males/Females) and I'd like to know the top diffentially expressed tags between all Males vs all Females. But I can't find a solution because performing all possible pair-wise tests in several libraries is statistically invalid and would lead to an unacceptable
accumulation of false positives.
I've searched through the litterature without success so far and the 3 packages I'm using don't seem to treat this kind of comparison.
I would appreciate any form of help (litterature, idea, R packages...)
Thank you
I'd like to compare multiple DGE librairies without replicates. I got 4 librairies that describe 4 different conditions (Young Males/Females , Old Males/Females) and I'd like to know the top diffentially expressed tags between all Males vs all Females. But I can't find a solution because performing all possible pair-wise tests in several libraries is statistically invalid and would lead to an unacceptable
accumulation of false positives.
I've searched through the litterature without success so far and the 3 packages I'm using don't seem to treat this kind of comparison.
I would appreciate any form of help (litterature, idea, R packages...)
Thank you
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