Dear everyone,
Does anybody here know how DEXSeq handles 3'bias (or any other bias) of read coverage of genes?
Would it report differential usage of exons in the 3' part of the gene if libraries of one treatment have 3'biased coverage and the libraries of the other sample does not?
Also, would it report the same differential exon usage if 1 or 2 out of 3 replicate libraries of one treatment has 3'bias and the other treatment has normal replicate libraries?
Thanks!
Does anybody here know how DEXSeq handles 3'bias (or any other bias) of read coverage of genes?
Would it report differential usage of exons in the 3' part of the gene if libraries of one treatment have 3'biased coverage and the libraries of the other sample does not?
Also, would it report the same differential exon usage if 1 or 2 out of 3 replicate libraries of one treatment has 3'bias and the other treatment has normal replicate libraries?
Thanks!
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