Hi,

The document of cufflink said that cuffdiff measured "distance" between relative abundances of a group of transcripts in two difference conditions by JS divergence, and assigned a p-value the observed changes based on the JS divergence. However, how did it get distribution or variance of test statistics under of null hypothesis? Thanks in advance.

The original document is at

http://cufflinks.cbcb.umd.edu/howitworks.html

Best.

Zhixing

The document of cufflink said that cuffdiff measured "distance" between relative abundances of a group of transcripts in two difference conditions by JS divergence, and assigned a p-value the observed changes based on the JS divergence. However, how did it get distribution or variance of test statistics under of null hypothesis? Thanks in advance.

The original document is at

http://cufflinks.cbcb.umd.edu/howitworks.html

Best.

Zhixing

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