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  • jisdb
    Junior Member
    • Apr 2016
    • 3
    #1

    DEXSeq and shrinkage diagnostic : Comparison between results in plotDispEsts( dxd )

    I run DEXSeq on my data. I have 16 individuals in each conditions (2 conditions). After computing the dispersions with estimateDispersions( dxd ), I plotted the graph plotDispEsts( dxd ) and I obtain this :



    I tried the others ways to fit (local and mean) but I obtained the same kind of shrinkage.

    Can you please tell me if my graph seems to be ok ? And if it's not, what it could be ?

    Moreover, is there any way to recover the normalized data ?

    Thanks for you help !
    Tags: dexseq, dexseq plot
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