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  • dindel question

    Hi all,

    In the dindel manual there is a paragraph that reads:
    Targeted resequencing: With targeted resequencing experiments, such as exome capture protocols, it is not possible to have reads on both the forward and the reverse strand at the boundary of a targeted region. Therefore these filters should be applied with care in those situations.

    Could anyone explain how this phenomenon could have occurred? My original thinking was that what ever that's successfully picked up by the probe and sequenced should have equal chance to see forward and reverse strand in theory. I must be missing something here.

    Thanks!

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