For ASE test, we do binomial test for each heterozygous SNP to see wheather it's ASE.
But Some transcripts will have more than one heterozygous SNP. However we tests each SNP independently. Is there any (...manageable) way to test if this gene is ASE?
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The complexity of cancer is clearly demonstrated in the diverse ecosystem of the tumor microenvironment (TME). The TME is made up of numerous cell types and its development begins with the changes that happen during oncogenesis. “Genomic mutations, copy number changes, epigenetic alterations, and alternative gene expression occur to varying degrees within the affected tumor cells,” explained Andrea O’Hara, Ph.D., Strategic Technical Specialist at Azenta. “As...07-08-2024, 03:19 PM