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  • Genetic and Epigenetic Interplay in Cancer Session at TCEC 2013

    Recent discoveries from the sequencing of various types of human cancers have revealed a remarkable amount of aberrantly expressed and mutated epigenetic-specific genes. The combination of known genetic contributors with a largely undefined epigenetic regulatory layer provides a clearer picture as to the complexity of factors initiating and driving the progression of cancers. This session of TCEC: The Clinical Epigenome Conference features presentations highlighting how cancer epigenomes influence the underlying genome, and vice versa, with this interplay working to produce disease outcomes.

    View meeting agenda: http://www.clinicalgenomeconference....ical-Epigenome

    Registration information: https://chidb.com/register/2013/clg/reg.asp (Early registration discount of up to $350 ends on March 29)

    FEATURED SESSION: GENETIC & EPIGENETIC INTERPLAY IN CANCER

    » KEYNOTE PRESENTATION
    Spontaneous and Therapy Induced Evolution of Tumor Genomes and Epigenomes
    Joseph Costello, Ph.D., Professor in Residence, Department of Neurological Surgery; Director, Epigenetics Division, Cell Cycling and Signaling Program, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco

    Distinguishing between Driver and Passenger Epigenetic Modifications in Cancer
    Daniel De Carvalho, Ph.D., Principal Investigator, Ontario Cancer Institute, University Health Network; Assistant Professor, Medical Biophysics, Faculty of Medicine, University of Toronto

    Constitutional BRCA1 Methylation and Cancer Predisposition
    Alexander Dobrovic, Ph.D., Head, Molecular Pathology Research & Development, Peter McCallum Cancer Centre

    » OTHER CONFERENCE TOPICS INCLUDE:

    - Mechanisms in (De)Methylation Underlying Development of Disease
    - The Predictive Power of Epigenetics: Diagnostic & Prognostic Utility
    - The Clinical Genome Technology Showcase
    - Trends in Analysis & Interpretation

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  • seqadmin
    Strategies for Sequencing Challenging Samples
    by seqadmin


    Despite advancements in sequencing platforms and related sample preparation technologies, certain sample types continue to present significant challenges that can compromise sequencing results. Pedro Echave, Senior Manager of the Global Business Segment at Revvity, explained that the success of a sequencing experiment ultimately depends on the amount and integrity of the nucleic acid template (RNA or DNA) obtained from a sample. “The better the quality of the nucleic acid isolated...
    03-22-2024, 06:39 AM
  • seqadmin
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    The field of conservation genomics centers on applying genomics technologies in support of conservation efforts and the preservation of biodiversity. This article features interviews with two researchers who showcase their innovative work and highlight the current state and future of conservation genomics.

    Avian Conservation
    Matthew DeSaix, a recent doctoral graduate from Kristen Ruegg’s lab at The University of Colorado, shared that most of his research...
    03-08-2024, 10:41 AM

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