Is there any version of hg38 genome that has no "N" at all (all ATGC)? I am trying to analyze the GC content of the telomere region, but most of it is "N" only. I heard that there is an "unmasked" version of hg38 genome that includes the most probable bases, but can't find it anywhere.
Another question is, is there any bed file that has the genomic coordinates for the telomere region of the chromosomes of the hg38 genome?
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The complexity of cancer is clearly demonstrated in the diverse ecosystem of the tumor microenvironment (TME). The TME is made up of numerous cell types and its development begins with the changes that happen during oncogenesis. “Genomic mutations, copy number changes, epigenetic alterations, and alternative gene expression occur to varying degrees within the affected tumor cells,” explained Andrea O’Hara, Ph.D., Strategic Technical Specialist at Azenta. “As...07-08-2024, 03:19 PM