fold change for genes with 0 reads

[rnaseq]

I am comparing Illumina RNA-seq data sets for differentially expressed genes. A significant number of genes have 0 reads in one of the two conditions. What is the best way to include these genes? Is it acceptable to subsitute the 0 in the numerator or denominator with another number to get an approximate idea of the fold change?

Thanks!

[malachig]

This appears to be a cross post. FAQ says not to do this...

In case anyone lands on this one, the post that has generated discussion is here.

[ECO]

Closed. Thanks malachig.