Originally posted by RCJK
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Personally, I don't have too many issues with the 454 library prep protcol. It's much easier than the Illumina one - no gel cut as standard, no PCR enrichment only 2 clean-ups. I don't think there's too much call for that being automated unless you wanted massive throughput. In that case, you it should be fairly automatable on most flatbeds.
However, I would welcome a "magic box" that does the breaking, enrichment and recovery though. Those steps are a pain in the you-know-what.
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