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  • paolo.kunder
    Member
    • Aug 2011
    • 93

    #1

    Bioinformatics position-Humanitas-Milano-Italy

    Bioinformatics position in the laboratory of Inflammation and immunology in cardiovascular pathologies at Humanitas:

    Our lab aims at understanding the molecular mechanisms of cardiovascular diseases, particularly heart failure and the broad spectrum of molecular events that control myocardial function, with a multilevel, bench to bedside methodology. ___ The challenge Heart failure is the clinical end-point of many cardiovascular diseases (CVDs), such as hypertension, myocardial infarction, cardiomyopathy and myocarditis. Despite the advancement in prevention and early diagnosis, these pathologies are the main cause of death and disabilities worldwide. By better understanding cellular and molecular mechanisms behind heart failure we could identify new therapeutic targets and dramatically improve the quality of life for millions of patients with CVDs. Main research areas Epigenetics of cardiovascular diseases We want to understand how risk factors and tissue damage modify gene expression in cells of the cardiovascular system and how such dysregulated gene expression affect cells behavior in the context of heart failure and atherosclerosis. Role of immune-inflammation in cardiovascular diseases In collaboration with other research groups at Humanitas Research Hospital and Humanitas University, we study the role that innate and acquired immunity play in remodeling myocardial tissues and in atherosclerosis. Our final goal is to better understand the involvement of the immune system in cardiovascular diseases, leading the way towards new therapeutic approaches targeting inflammation in CVDs. Innovative biomarkers of cardiovascular diseases By studying the downstream molecules produced by gene expression reprogramming and immune-inflammation in CVDs, we aim at identifying new biomarkers with diagnostic and prognostic value for disease assessment.


    Start date: November 2014
    Contact Person (Referent): Paolo Kunderfranco
    Ref. E-Mail: [email protected]

    Job Description:
    We are looking for a young scientist (24 - 28 years old) with a strong interest in transcriptomics and epigenetics filed. The successful candidate will work in collaboration with biologists and will be in charge of developing computational and statistical methods to analyse and integrate next-generation sequencing data, including ChIP-Seq, Exome-Seq and RNA-Seq data.

    Main Activities:
    - Process and analyse high throughput DNA and RNA sequencing data from a NGS sequencing platform.
    - Develop, optimize and run NGS analysis pipeline and data management systems.

    Candidates should submit a CV and a brief personal statement focusing on their skills and interests related to the position.
    Last edited by paolo.kunder; 09-18-2014, 11:51 PM.

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