Most significant discoveries using NGSTs

[jgibbons1]

Hi everyone,
Although in their infancy, NGSTs are transforming biological research. I was hoping to hear the seqanswers community take on this question:

What are the biggest/most significant discoveries yielded by NGST thus far?

Looking forward to hearing your thoughts.

[chadn737]

Not an exhaustive list, just what comes to mind

1) New unsequenced genomes

2) Ancient genomes (Neanderthal, Denisovan, etc)

3) That there is a lot more transcribed regions, non-coding RNAs, alternative splicing, etc than was previously known

4) Single-base resolution of Methylation

5) The rate of new mutations

[jgibbons1]

Thanks for your thoughts.

Another - 6) The prevalence of horizontal gene transfer

[krobison]

Cancer genomics -- many new driver mutations, both point and fusion

Bacterial pan genomes -- size of some pan genomes

Vertebrate pan genomes -- all that was missed the first time through