Cancer genomics -- many new driver mutations, both point and fusion
Bacterial pan genomes -- size of some pan genomes
Vertebrate pan genomes -- all that was missed the first time through
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Thanks for your thoughts.
Another - 6) The prevalence of horizontal gene transfer
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Not an exhaustive list, just what comes to mind
1) New unsequenced genomes
2) Ancient genomes (Neanderthal, Denisovan, etc)
3) That there is a lot more transcribed regions, non-coding RNAs, alternative splicing, etc than was previously known
4) Single-base resolution of Methylation
5) The rate of new mutations
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Most significant discoveries using NGSTs
Hi everyone,
Although in their infancy, NGSTs are transforming biological research. I was hoping to hear the seqanswers community take on this question:
What are the biggest/most significant discoveries yielded by NGST thus far?
Looking forward to hearing your thoughts.Tags: None
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by seqadmin
The complexity of cancer is clearly demonstrated in the diverse ecosystem of the tumor microenvironment (TME). The TME is made up of numerous cell types and its development begins with the changes that happen during oncogenesis. “Genomic mutations, copy number changes, epigenetic alterations, and alternative gene expression occur to varying degrees within the affected tumor cells,” explained Andrea O’Hara, Ph.D., Strategic Technical Specialist at Azenta. “As...-
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