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Our paper about re-analysis public dataset from novel angle !!!
The starting point are two simply questions:
Question 1: For a chunk of DNA, if I tell you that the base content [A] = 20%, what is the base content [T]? How about [G] and [C]?
> Are you kidding? Everybody knows this. And the answer is [T]=20%, [G]=30%, and [C]=30%.
Question 2: If I unzip the DNA double helix and throw one strand away, I now have a single strand in my hand (which is the way for genome sequences deposited in GenBank). For this single strand , if I tell you that the base content [A] = 20%, what is the base content [T]? How about [G] and [C]?
> Most answers are: because of the degrees of freedom for 4 nucleotides is 3, so you can't estimate it. But, hold your thought and find the clue from the attached graph
By focusing on [A] on single strand, a lot of interesting things were discovered!
Check out the whole story at http://nar.oxfordjournals.org/conten...ar.gkv197.full
The starting point are two simply questions:
Question 1: For a chunk of DNA, if I tell you that the base content [A] = 20%, what is the base content [T]? How about [G] and [C]?
> Are you kidding? Everybody knows this. And the answer is [T]=20%, [G]=30%, and [C]=30%.
Question 2: If I unzip the DNA double helix and throw one strand away, I now have a single strand in my hand (which is the way for genome sequences deposited in GenBank). For this single strand , if I tell you that the base content [A] = 20%, what is the base content [T]? How about [G] and [C]?
> Most answers are: because of the degrees of freedom for 4 nucleotides is 3, so you can't estimate it. But, hold your thought and find the clue from the attached graph
By focusing on [A] on single strand, a lot of interesting things were discovered!
Check out the whole story at http://nar.oxfordjournals.org/conten...ar.gkv197.full