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  • Quantifying gene expression at the level of translation: Ribo-seq in tissue

    We performed ribosome profiling of the heart and liver of two inbred rat strains. Our results suggest that:

    - Ribo-seq is a better proxy for protein levels than RNA-seq
    - There is widespread regulation of gene expression AFTER transcription
    - Integration of RNA-seq and Ribo-seq reveals translational control and opens up a new level of gene regulation for further studies

    Read the full manuscript here:

    Translational regulation shapes the molecular landscape of complex disease phenotypes - Nature Communications

    The Ribo-seq data used in this study is of course publicly available and we believe we have generated some of the deepest datasets to date with 5 biological replicates for each condition.

Latest Articles

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  • seqadmin
    Strategies for Sequencing Challenging Samples
    by seqadmin


    Despite advancements in sequencing platforms and related sample preparation technologies, certain sample types continue to present significant challenges that can compromise sequencing results. Pedro Echave, Senior Manager of the Global Business Segment at Revvity, explained that the success of a sequencing experiment ultimately depends on the amount and integrity of the nucleic acid template (RNA or DNA) obtained from a sample. “The better the quality of the nucleic acid isolated...
    03-22-2024, 06:39 AM
  • seqadmin
    Techniques and Challenges in Conservation Genomics
    by seqadmin



    The field of conservation genomics centers on applying genomics technologies in support of conservation efforts and the preservation of biodiversity. This article features interviews with two researchers who showcase their innovative work and highlight the current state and future of conservation genomics.

    Avian Conservation
    Matthew DeSaix, a recent doctoral graduate from Kristen Ruegg’s lab at The University of Colorado, shared that most of his research...
    03-08-2024, 10:41 AM

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