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Quantitative analysis of DNA methylation of imprinted genes in single human blastocysts by pyrosequencing.
Fertil Steril. 2011 May 14;
Authors: Huntriss J, Woodfine K, Huddleston JE, Murrell A, Rutherford AJ, Elder K, Khan AA, Hemmings K, Picton H
We report the first quantitative assessment of DNA methylation for any gene in the human preimplantation embryo to reveal that imprints exist at KvDMR1, RB1, SNRPN, and GRB10 in the human blastocyst. For comparison, in two human embryonic stem cell lines, imprints were also observed at KvDMR1, SNRPN, GRB10, and other imprinted loci, whereas RB1 and MEG3 were hypermethylated.
PMID: 21575943 [PubMed - as supplied by publisher]
More...
Quantitative analysis of DNA methylation of imprinted genes in single human blastocysts by pyrosequencing.
Fertil Steril. 2011 May 14;
Authors: Huntriss J, Woodfine K, Huddleston JE, Murrell A, Rutherford AJ, Elder K, Khan AA, Hemmings K, Picton H
We report the first quantitative assessment of DNA methylation for any gene in the human preimplantation embryo to reveal that imprints exist at KvDMR1, RB1, SNRPN, and GRB10 in the human blastocyst. For comparison, in two human embryonic stem cell lines, imprints were also observed at KvDMR1, SNRPN, GRB10, and other imprinted loci, whereas RB1 and MEG3 were hypermethylated.
PMID: 21575943 [PubMed - as supplied by publisher]
More...