NGS has revolutionized clinical microbiology by offering new ways to identify and surveil pathogens without prior knowledge of the target. One popular approach is 16S rRNA and ITS amplicon sequencing, which targets specific microbial markers. But studies are increasingly incorporating shotgun metagenomics, a technique that sequences all DNA from a sample without targeting specific microbial markers. This approach allows more detailed taxonomic classification, detection...
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16S/ITS Profiling vs. Shotgun Metagenomics: What Changes in Your Workflow?
NGS has revolutionized clinical microbiology by offering new ways to identify and surveil pathogens without prior knowledge of the target. One popular approach is 16S rRNA and ITS amplicon sequencing, which targets specific microbial markers. But studies are increasingly incorporating shotgun metagenomics, a technique that sequences all DNA from a sample without targeting specific microbial markers. This approach allows more detailed taxonomic classification, detection...Last edited by SEQadmin2; Yesterday, 06:55 AM. -
Multiomic Liquid Biopsy: What DNA/RNA Panels Reveal That DNA Alone Can’t
Tumors contain complex mixtures of cell populations that evolve in response to treatment and host-specific factors. Tissue biopsies provide only static snapshots of a tumor’s state. But what if we could follow that evolution over time using a minimally invasive technique?
Liquid biopsies can detect tumor-derived material circulating in the bloodstream, providing a way to study treatment response, detect emerging resistance, and discover new biomarkers. Circulating...Last edited by SEQadmin2; 10-14-2026, 10:06 AM. -
New Genomics Technologies Take Aim at Long-Standing Limits
Researchers using sequencing and genomics tools often have to make trade-offs. They can choose between speed or scale, short reads or long-range information, or targeted panels or a view of the whole transcriptome. New technologies that have been released this year are built to address those tough choices.
We asked six companies the same four questions to learn about their latest products. The new technologies bring a lot to the table, including rethinking sequencing...Last edited by SEQadmin2; 09-28-2026, 10:37 AM. -
How Immunogenomics Decodes Immunity’s Genetic Blueprint
The immune system’s power comes from its genetic diversity, allowing myriad threats to be neutralized through first recognizing foreign antigens. That diversity is also what makes the immune system so difficult to study. Recent advances in sequencing technology and computational biology, however, are giving researchers new tools to understand immune responses and immune-related diseases in greater detail.
This convergence of genetics, immunology, and computation...Last edited by SEQadmin2; 09-01-2026, 05:58 AM. -
Beyond CRISPR/Cas9: Understand, Choose, and Use the Right Genome Editing Tool
CRISPR/Cas9 sparked the gene editing revolution for both research and therapeutics.1 But this system still showed severe issues that limited its applications. The most prominent were the heavy reliance on PAM sequences, delivery limitations, double-stranded breaks that prompt unintended edits and cell death, and editing inefficiency (both in targeting and in knock-in reliability).
Despite this, “CRISPR helped turn genome editing from a specialized technique into...Last edited by SEQadmin2; 08-03-2026, 10:43 AM. -
Proteomic Platforms: How to Choose the Right Analytical Strategy to Improve Detection and Clinical Applications
Proteomics platforms are evolving rapidly, with advances in mass spectrometry and affinity-based approaches expanding what researchers can detect and at what scale. As the field moves toward deeper proteome coverage and clinical applications, scientists face an increasingly complex landscape of tools. This article will explore how researchers are navigating these choices to find the right platform for their work.
The systematic characterization of the human proteome has...Last edited by SEQadmin2; 07-20-2026, 11:54 AM. -
Advanced Sequencing Platforms Tackle Neuroscience’s Toughest Genomics Problems
Genomics studies in neuroscience face a special challenge due to the brain’s complexity and scarcity of samples. Mapping changes in cell type and state using conventional next-generation sequencing methods remains challenging. Advances in technologies like single-cell sequencing, spatial transcriptomics, and long-read sequencing have opened the door to deeper studies of the brain and diseases like Alzheimer’s, amyotrophic lateral sclerosis (ALS), and schizophrenia.
...Last edited by SEQadmin2; 07-09-2026, 12:35 PM. -
Cancer Drug Resistance: The Lingering Barrier to Rising Survival
Cancer survival rates have significantly increased in the last few decades in the United States, reaching a combined 70% 5-year survival rate by 2021. Behind this number, there are years of research to find new therapies, drug targets, and early detection methods. But there is one core challenge that keeps slowing down these advances, and it’s about drug resistance.
There is no single reason why many patients don’t respond to treatment as expected. Cancer is... -
Nine Things a Sample Prep Scientist Thinks About Before Sequencing
I’m not a sequencing expert. I’m a purification scientist who uses NGS to evaluate workflows my group develops. With this perspective, we think about the sample first and the NGS workflow second. The sequencer is an exceptionally honest reporter, but it can only report on what you give it, so whether you get clean, interpretable data from an NGS workflow is largely determined before you begin.
Here are nine questions we think about, in roughly the order they matter, before...Last edited by SEQadmin2; 06-24-2026, 01:31 AM. -
From Collection to Sequencing: Why Sample Preparation and Preservation Define Sequencing Data
Data variability is still an issue in sequencing technologies despite the advances in reproducibility and accuracy of these platforms. But the problem does not originate in the sequencing itself, but in the previous steps, before the sample reaches the sequencer.
The first step is collection, followed by preservation and sample preparation for analysis. Most scientists overlook those steps, but not being careful might just be skewing the experiment’s results.
...Last edited by SEQadmin2; 06-02-2026, 10:17 AM. -
Single-Cell Sequencing at an Inflection Point: Early Impacts of New Platforms and Emerging Trends
With the launch of new single-cell sequencing platforms in 2026, the field stands at an exciting inflection point. This article surveys the most impactful advances in the field and discusses how they’re reshaping research in cancer, immunology, and beyond.
Introduction
Single-cell sequencing technologies have undergone remarkable advances over the past decade, transitioning from low-throughput experimental approaches to highly scalable platforms capable of...Last edited by SEQadmin2; 05-26-2026, 09:50 AM. -
Environmental Genomics in the Age of NGS: From Microbes to Conservation Strategies
Studying ecosystems means dealing with complex, multi-species communities that are hard to observe at scale. This complexity, however, hides many important questions to be answered, from how biogeochemical cycles work and how climate change can affect species distribution to how conservation strategies can work best.
Genomics, particularly since the expansion of NGS, has transformed ecosystem ecology. By sequencing environmental DNA, we can now assess biodiversity without direct...Last edited by SEQadmin2; 05-28-2026, 03:29 AM. -
Decoding Gene Regulation Through Epigenomic Tools
Epigenomic profiling is transforming how researchers study gene regulation by revealing the DNA, chromatin, and RNA-based mechanisms that control cellular identity and response to environmental cues. While genomics shows what is possible and transcriptomics shows what is happening, epigenomics explains how regulatory states are established and maintained across tissues and disease contexts.
This article from Biocompare reviews major epigenomic methods, including...Last edited by SEQadmin2; 06-02-2026, 10:20 AM. -
New Tools for Old Evidence: How Advanced Sequencing Is Revolutionizing Forensic Genomics
Nearly four decades ago, DNA analysis was introduced into forensic practice, transforming the criminal investigation process. The first methods were labor-intensive, requiring large amounts of high-quality biological material. The emergence of polymerase chain reaction (PCR), which amplifies tiny quantities of DNA into detectable amounts, made routine forensic testing practical. Today, short tandem repeat (STR) profiling via capillary electrophoresis (CE) is the mainstay of forensic...Last edited by SEQadmin2; 06-02-2026, 10:24 AM. -
Multiomics in the Era of Translational and Precision Medicine
Genomics has provided actionable clinical information, helping diagnose rare diseases, identify tumor mutations linked to treatment resistance, and find new drug targets.
But clinicians often face a problem: two tumors with the same mutation can respond differently to chemotherapy, and two patients with the same symptoms can carry entirely different DNA alterations.
The reason lies in the complexity of disease regulation. Changes in splicing, transcription,...Last edited by SEQadmin2; 03-23-2026, 08:58 AM.