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cancer
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  • Cancer Drug Resistance: The Lingering Barrier to Rising Survival

    Cancer Drug Resistance: The Lingering Barrier to Rising Survival




    Cancer survival rates have significantly increased in the last few decades in the United States, reaching a combined 70% 5-year survival rate by 2021. Behind this number, there are years of research to find new therapies, drug targets, and early detection methods. But there is one core challenge that keeps slowing down these advances, and it’s about drug resistance.

    There is no single reason why many patients don’t respond to treatment as expected. Cancer is...
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  • Single-Cell Sequencing at an Inflection Point: Early Impacts of New Platforms and Emerging Trends



    With the launch of new single-cell sequencing platforms in 2026, the field stands at an exciting inflection point. This article surveys the most impactful advances in the field and discusses how they’re reshaping research in cancer, immunology, and beyond.


    Introduction

    Single-cell sequencing technologies have undergone remarkable advances over the past decade, transitioning from low-throughput experimental approaches to highly scalable platforms capable of...
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    Last edited by SEQadmin2; 05-26-2026, 09:50 AM.

  • Multiomics in the Era of Translational and Precision Medicine

    Multiomics in the Era of Translational and Precision Medicine



    Genomics has provided actionable clinical information, helping diagnose rare diseases, identify tumor mutations linked to treatment resistance, and find new drug targets.


    But clinicians often face a problem: two tumors with the same mutation can respond differently to chemotherapy, and two patients with the same symptoms can carry entirely different DNA alterations.

    The reason lies in the complexity of disease regulation. Changes in splicing, transcription,...
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    Last edited by SEQadmin2; 03-23-2026, 08:58 AM.

  • Decoding the Tumor Microenvironment with Next-Generation Sequencing




    Cancer is increasingly understood as an ecosystem in which tumor cells co-evolve with immune, stromal, and vascular components of the surrounding tumor microenvironment (TME). These interactions affect disease progression, therapeutic response, and the emergence of resistance. Yet, the molecular mechanisms underlying these processes have long been difficult to resolve. Next-generation sequencing (NGS) technologies now enable high-resolution analysis of this dynamic landscape....
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    Last edited by SEQadmin2; 03-23-2026, 05:13 AM.

  • Exploring the Dynamics of the Tumor Microenvironment

    Exploring the Dynamics of the Tumor Microenvironment





    The complexity of cancer is clearly demonstrated in the diverse ecosystem of the tumor microenvironment (TME). The TME is made up of numerous cell types and its development begins with the changes that happen during oncogenesis. “Genomic mutations, copy number changes, epigenetic alterations, and alternative gene expression occur to varying degrees within the affected tumor cells,” explained Andrea O’Hara, Ph.D., Strategic Technical Specialist at Azenta. “As...
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  • Advanced Tools Transforming the Field of Cytogenomics

    Advanced Tools Transforming the Field of Cytogenomics



    At the intersection of cytogenetics and genomics lies the exciting field of cytogenomics. It focuses on studying chromosomes at a molecular scale, involving techniques that analyze either the whole genome or particular DNA sequences to examine variations in structure and behavior at the chromosomal or subchromosomal level. By integrating cytogenetic techniques with genomic analysis, researchers can effectively investigate chromosomal abnormalities related to diseases, particularly...
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  • How RNA-Seq is Transforming Cancer Studies

    How RNA-Seq is Transforming Cancer Studies




    Cancer research has been transformed through numerous molecular techniques, with RNA sequencing (RNA-seq) playing a crucial role in understanding the complexity of the disease. Maša Ivin, Ph.D., Scientific Writer at Lexogen, and Yvonne Goepel Ph.D., Product Manager at Lexogen, remarked that “The high-throughput nature of RNA-seq allows for rapid profiling and deep exploration of the transcriptome.” They emphasized its indispensable role in cancer research, aiding in biomarker...
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