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  • New Genomics Technologies Take Aim at Long-Standing Limits

    New Genomics Technologies Take Aim at Long-Standing Limits



    Researchers using sequencing and genomics tools often have to make trade-offs. They can choose between speed or scale, short reads or long-range information, or targeted panels or a view of the whole transcriptome. New technologies that have been released this year are built to address those tough choices.

    We asked six companies the same four questions to learn about their latest products. The new technologies bring a lot to the table, including rethinking sequencing
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    Last edited by SEQadmin2; 09-28-2026, 10:37 AM.

  • How Immunogenomics Decodes Immunity’s Genetic Blueprint

    How Immunogenomics Decodes Immunity’s Genetic Blueprint





    The immune system’s power comes from its genetic diversity, allowing myriad threats to be neutralized through first recognizing foreign antigens. That diversity is also what makes the immune system so difficult to study. Recent advances in sequencing technology and computational biology, however, are giving researchers new tools to understand immune responses and immune-related diseases in greater detail.

    This convergence of genetics, immunology, and computation...
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    Last edited by SEQadmin2; 09-01-2026, 05:58 AM.

  • Advanced Sequencing Platforms Tackle Neuroscience’s Toughest Genomics Problems




    Genomics studies in neuroscience face a special challenge due to the brain’s complexity and scarcity of samples. Mapping changes in cell type and state using conventional next-generation sequencing methods remains challenging. Advances in technologies like single-cell sequencing, spatial transcriptomics, and long-read sequencing have opened the door to deeper studies of the brain and diseases like Alzheimer’s, amyotrophic lateral sclerosis (ALS), and schizophrenia.
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    Last edited by SEQadmin2; 07-09-2026, 12:35 PM.

  • Nine Things a Sample Prep Scientist Thinks About Before Sequencing



    I’m not a sequencing expert. I’m a purification scientist who uses NGS to evaluate workflows my group develops. With this perspective, we think about the sample first and the NGS workflow second. The sequencer is an exceptionally honest reporter, but it can only report on what you give it, so whether you get clean, interpretable data from an NGS workflow is largely determined before you begin.

    Here are nine questions we think about, in roughly the order they matter, before...
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    Last edited by SEQadmin2; 06-24-2026, 01:31 AM.

  • From Collection to Sequencing: Why Sample Preparation and Preservation Define Sequencing Data



    Data variability is still an issue in sequencing technologies despite the advances in reproducibility and accuracy of these platforms. But the problem does not originate in the sequencing itself, but in the previous steps, before the sample reaches the sequencer.


    The first step is collection, followed by preservation and sample preparation for analysis. Most scientists overlook those steps, but not being careful might just be skewing the experiment’s results.
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    Last edited by SEQadmin2; 06-02-2026, 10:17 AM.

  • New Tools for Old Evidence: How Advanced Sequencing Is Revolutionizing Forensic Genomics



    Nearly four decades ago, DNA analysis was introduced into forensic practice, transforming the criminal investigation process. The first methods were labor-intensive, requiring large amounts of high-quality biological material. The emergence of polymerase chain reaction (PCR), which amplifies tiny quantities of DNA into detectable amounts, made routine forensic testing practical. Today, short tandem repeat (STR) profiling via capillary electrophoresis (CE) is the mainstay of forensic
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    Last edited by SEQadmin2; 06-02-2026, 10:24 AM.

  • Multiomics in the Era of Translational and Precision Medicine

    Multiomics in the Era of Translational and Precision Medicine



    Genomics has provided actionable clinical information, helping diagnose rare diseases, identify tumor mutations linked to treatment resistance, and find new drug targets.


    But clinicians often face a problem: two tumors with the same mutation can respond differently to chemotherapy, and two patients with the same symptoms can carry entirely different DNA alterations.

    The reason lies in the complexity of disease regulation. Changes in splicing, transcription,...
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    Last edited by SEQadmin2; 03-23-2026, 08:58 AM.

  • Population Genomics: Applications in Healthcare, Conservation, Agriculture, and More


    Foundation, co-evolution with NGS, and impact

    Population genomics is the use of DNA data from entire populations to understand the genetic makeup of a group of individuals, human or otherwise. We previously covered the basics of population genomics and how next-generation sequencing (NGS) expanded the field here.1 Since then, population genomics has co-evolved with NGS to achieve measurable impacts in several areas.

    This article will cover:

    ● How
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    Last edited by SEQadmin2; 03-09-2026, 07:49 AM.

  • Decoding the Tumor Microenvironment with Next-Generation Sequencing




    Cancer is increasingly understood as an ecosystem in which tumor cells co-evolve with immune, stromal, and vascular components of the surrounding tumor microenvironment (TME). These interactions affect disease progression, therapeutic response, and the emergence of resistance. Yet, the molecular mechanisms underlying these processes have long been difficult to resolve. Next-generation sequencing (NGS) technologies now enable high-resolution analysis of this dynamic landscape....
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    Last edited by SEQadmin2; 03-23-2026, 05:13 AM.

  • NGS Advances as Tool for Synthetic Biology DBTL Cycle

    NGS Advances as Tool for Synthetic Biology DBTL Cycle







    Synthetic biology has advanced quickly in the last decade, and a lot of that is because of next-generation sequencing (NGS). In synthetic biology, engineering principles are applied to biological systems, to modify or create new biological organisms or molecules. Because of this, the working paradigm is the design-build-test-learn (DBTL) cycle.

    With the instructions to every organism, system, or molecule being encoded in DNA, NGS is crucial
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    Last edited by SEQadmin2; 03-23-2026, 05:14 AM.

  • How AI Is Changing NGS Workflows

    How AI Is Changing NGS Workflows



    Current NGS technologies easily deliver terabases of data in a single run. At the same time, AI is on the rise, with many touting its potential for handling complex, high-volume information. In this article, we will break down how AI models are being implemented in NGS from primary to tertiary analysis, and whether they pose an advantage in accuracy, speed, and genomic insights.

    Basecalling: where chemistry determines impact

    Basecalling is a foundational step...
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    Last edited by SEQadmin2; 02-03-2026, 07:24 AM.

  • High-Speed Genomic Sequencing Is Transforming Pediatric Rare Disease Diagnosis


    The Human Genome Project generated the human reference genome over 13 years at a cost of $3 billion.1 That massive undertaking used the low-throughput Sanger method, which sequences one DNA fragment at a time. While this strategy remains useful for interrogating small genomic regions, modern next-generation sequencing (NGS) technologies can simultaneously sequence millions of fragments in a single run, enabling the analysis of hundreds to thousands of genes at once.

    Today, rapid
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    Last edited by mdimapilis; 01-16-2026, 01:48 PM.

  • The Diverse Applications of Ancient DNA Research

    The Diverse Applications of Ancient DNA Research







    For many, the idea of ancient DNA (aDNA) can invoke images from the iconic movie scene with a mosquito trapped in amber, or perhaps one of the real discoveries involving a woolly mammoth perfectly preserved in ice1. However, this field is much more than unearthing prehistoric animals or a real project working to resurrect them2. The study of aDNA is vital for interpreting the past and making sense of the present. For example, Swedish geneticist Svante Pääbo...
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  • Strategies for Investigating the Microbiome

    Strategies for Investigating the Microbiome





    Microbiome research has led to the discovery of important connections to human and environmental health. Sequencing has become a core investigational tool in microbiome research, a subject that we covered during a recent webinar. Our expert speakers shared a number of advancements including improved experimental workflows, research involving transmission dynamics, and invaluable analysis resources. This article recaps their informative presentations, offering insights...
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  • Thermo Fisher Scientific: Spotlight on the Companies Shaping Genetic Research



    Within the extensive array of instruments that Thermo Fisher Scientific offers, their Ion Torrent Next-Generation Sequencing systems remain important technologies for genomic research. Introduced in 2010 with the Ion PGM System (Personal Genome Machine), these sequencers have been continually evolving and facilitating new scientific insights.

    After over a decade in the sequencing market, Jose Luis Costa, Global Director of Scientific Affairs at Thermo Fisher Scientific,
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