The BWA manual refers to "edit distance". What does this mean?
Eric
Eric
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It's the amount of difference between two sequences; your read, and your reference. -
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Below is from BWA.aln documentation:
"The maximum edit distance. This specifies a threshold of the maximum number of deletions, insertions, and substitutions needed to transform the reference sequence into the read sequence."Comment
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NGS has revolutionized clinical microbiology by offering new ways to identify and surveil pathogens without prior knowledge of the target. One popular approach is 16S rRNA and ITS amplicon sequencing, which targets specific microbial markers. But studies are increasingly incorporating shotgun metagenomics, a technique that sequences all DNA from a sample without targeting specific microbial markers. This approach allows more detailed taxonomic classification,...10-30-2026, 06:46 AM
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