When annotating a eukaryotic genome de novo, I find it tricky to identify gene models that in reality are two genes that are incorrectly fused. Rather than correctly identifying the stop codon, the gene finder adds an intron and continues the gene model into what really is a neighboring gene. I was just wondering what you do to identify these incorrectly fused gene models. Blasting all gene models is probably the obvious start, but then how to fish out the incorrectly fused ones and visualize the results? Are there any available tools that does this?
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Tumors contain complex mixtures of cell populations that evolve in response to treatment and host-specific factors. Tissue biopsies provide only static snapshots of a tumor’s state. But what if we could follow that evolution over time using a minimally invasive technique?
Liquid biopsies can detect tumor-derived material circulating in the bloodstream, providing a way to study treatment response, detect emerging resistance, and discover new biomarkers. Circulating...10-14-2026, 09:55 AM
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