Unconfigured Ad

Collapse
X
Collapse
 
  • Page of 1
  • Time
  • Show
Clear All
new posts
Previous template Next
  • adrian
    Member
    • Oct 2009
    • 90
    #1

    How can estimate the required coverage

    Hi all:

    I do not know how to answer a very simple question. I request you to help me.

    How do I know what is the required coverage for a 2 KB region. Someone asked me what is coverage needed to find a very low frequent mutation (10-5 10 to power -5). He wants to find mutation in one locus in a 2KB region. He asked me what is the coverage he should aim for?

    To be honest, I do not know how to answer that question. Could someone help me here please.

    thanks
    Adrian
    Tags: None
    Previous template Next

    Latest Articles

    Collapse
    • SEQadmin2
      Multiomic Liquid Biopsy: What DNA/RNA Panels Reveal That DNA Alone Can’t
      by SEQadmin2



      Tumors contain complex mixtures of cell populations that evolve in response to treatment and host-specific factors. Tissue biopsies provide only static snapshots of a tumor’s state. But what if we could follow that evolution over time using a minimally invasive technique?

      Liquid biopsies can detect tumor-derived material circulating in the bloodstream, providing a way to study treatment response, detect emerging resistance, and discover new biomarkers. Circulating      ...
      10-14-2026, 09:55 AM
    • SEQadmin2
      New Genomics Technologies Take Aim at Long-Standing Limits
      by SEQadmin2


      Researchers using sequencing and genomics tools often have to make trade-offs. They can choose between speed or scale, short reads or long-range information, or targeted panels or a view of the whole transcriptome. New technologies that have been released this year are built to address those tough choices.

      We asked six companies the same four questions to learn about their latest products. The new technologies bring a lot to the table, including rethinking sequencing      ...
      09-28-2026, 10:25 AM
    View All

    ad_right_rmr

    Collapse

    News

    Collapse
    Topics Statistics Last Post
    Exeter-Led Study Maps What an Average Human Genome Looks Like by SEQadmin2
    Started by SEQadmin2, Yesterday, 11:13 AM
    0 responses
    19 views
    0 reactions
    		 Last Post SEQadmin2
    by SEQadmin2
    Yesterday, 11:13 AM  
    Long-Read Sequencing Uncovers Cancer Mutations Conventional Testing Missed by SEQadmin2
    Started by SEQadmin2, Yesterday, 10:48 AM
    0 responses
    18 views
    0 reactions
    		 Last Post SEQadmin2
    by SEQadmin2
    Yesterday, 10:48 AM  
    Mayo Clinic-Led Study Detects DNA Mutations Across Noncancerous Tissues by SEQadmin2
    Started by SEQadmin2, 10-15-2026, 10:52 AM
    0 responses
    36 views
    0 reactions
    		 Last Post SEQadmin2
    by SEQadmin2
    10-15-2026, 10:52 AM  
    Study Finds Chromatin Motion Holds Steady Until Cells Face Stress by SEQadmin2
    Started by SEQadmin2, 10-14-2026, 05:39 AM
    0 responses
    42 views
    0 reactions
    		 Last Post SEQadmin2
    by SEQadmin2
    10-14-2026, 05:39 AM  
    View All
    Working...