Hello,
I am trying to detect mutations (SNPs, insertions and deletions) from DNA-seq data. I have both reference and tumoral samples.
I am convinced that a simultaneous comparison of both samples is more rigorous than a "subtraction" method based on independent analyses. Thus, I'm interested in tools allowing simultaneous comparison.
I have tried VarScan but there are important bugs in it.
I have found JointSNVMix combined with mutationSeq.
Could you suggest me other tools for this problematic?
Thanks,
Jane
I am trying to detect mutations (SNPs, insertions and deletions) from DNA-seq data. I have both reference and tumoral samples.
I am convinced that a simultaneous comparison of both samples is more rigorous than a "subtraction" method based on independent analyses. Thus, I'm interested in tools allowing simultaneous comparison.
I have tried VarScan but there are important bugs in it.
I have found JointSNVMix combined with mutationSeq.
Could you suggest me other tools for this problematic?
Thanks,
Jane
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