Hi,
Im a biochemistry student and im having trouble answeing a question which my report is based on, below is the question;
A number of single nucleotide polymorphisms (SNP) have been identified in the protein, apolipoprotein L1 (apoL1) which is just one member of a family of six conserved proteins. You will perform computer analysis to identify SNPs in apoL1 and the other five members of this protein family.
I just need to be pointedin the right direction, so far this is what i have:
now im not quite sure how to "find" SNP's as i do not have ny sequences of my own. As represented in the link above, is this the way to identify SNP's, the mrna sequence NM_003661.3, is mapped onto the contig chromosome 22 sequence NT_011520.12.
Using CLustal W i aligned the mrna to the contig chromosome sequence but the SNP's are not on the sequence.
This is very confusing, can i actually find any other SNP or do i just use the ones on the dbSNP?
if anyone could help me in anyway i would greatly apprciate it!
Thanks
Firat
Im a biochemistry student and im having trouble answeing a question which my report is based on, below is the question;
A number of single nucleotide polymorphisms (SNP) have been identified in the protein, apolipoprotein L1 (apoL1) which is just one member of a family of six conserved proteins. You will perform computer analysis to identify SNPs in apoL1 and the other five members of this protein family.
I just need to be pointedin the right direction, so far this is what i have:
now im not quite sure how to "find" SNP's as i do not have ny sequences of my own. As represented in the link above, is this the way to identify SNP's, the mrna sequence NM_003661.3, is mapped onto the contig chromosome 22 sequence NT_011520.12.
Using CLustal W i aligned the mrna to the contig chromosome sequence but the SNP's are not on the sequence.
This is very confusing, can i actually find any other SNP or do i just use the ones on the dbSNP?
if anyone could help me in anyway i would greatly apprciate it!
Thanks
Firat
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