Are you looking for a needle in a haystack? Well, GeneTalk might help you with filtering and annotating your sequence variants:
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If you click on the more button in the vcfViewer in GeneTalk you can see the HGVS code of the variant and are linked to the MutationTaster prediction:
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If you set the annotation filter, you will get all variants in your vcf file that have a GeneTalk User annotation or a scientific article linked to the specific mutationComment
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Hi,
we really had quite a high server load after these posts, so GeneTalk crashed several times over the last three days. However, now we scaled up the hardware (three servers in parallele) and all new users should be able to get their data filtered in a few seconds again,...Comment
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removing artefacts from variant list
In the 1000 genomes project more than 7 Mio variant calls were classified as probably false positives. These artefact positions are now marked by a lightning in GeneTalk (www.gene-talk.de) and can be filtered out.
In a usual exome we filter out between 1-2% of the variants based on this blacklist. Many of these artefacts don't have dbSNP IDs yet. Thus removing these artefacts might really speed up your NGS analysis!Comment
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Tumors contain complex mixtures of cell populations that evolve in response to treatment and host-specific factors. Tissue biopsies provide only static snapshots of a tumor’s state. But what if we could follow that evolution over time using a minimally invasive technique?
Liquid biopsies can detect tumor-derived material circulating in the bloodstream, providing a way to study treatment response, detect emerging resistance, and discover new biomarkers. Circulating...10-14-2026, 09:55 AM -
Researchers using sequencing and genomics tools often have to make trade-offs. They can choose between speed or scale, short reads or long-range information, or targeted panels or a view of the whole transcriptome. New technologies that have been released this year are built to address those tough choices.
We asked six companies the same four questions to learn about their latest products. The new technologies bring a lot to the table, including rethinking sequencing...
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