How is FASTQC determining encoding in basic summary? Their documentation doesn't seem to cover anything in regard?
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Well, you probably should write to the authors if you want to know. As a guess I suspect that it is looking at all of the quality values and then determining the lowest and highest value it sees. From there it would be quite easy to figure out the encoding used.
In other words, given only one sequence it is hard to tell what the encoding is. Given 1,000,000 sequences it would be trivial.
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CRISPR/Cas9 sparked the gene editing revolution for both research and therapeutics.1 But this system still showed severe issues that limited its applications. The most prominent were the heavy reliance on PAM sequences, delivery limitations, double-stranded breaks that prompt unintended edits and cell death, and editing inefficiency (both in targeting and in knock-in reliability).
Despite this, “CRISPR helped turn genome editing from a specialized technique into...07-31-2026, 11:01 AM
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